Proinflammatory Cytokine Inhibitor Prolongs the Survival of Rats With Heart Failure Induced by Pressure Overload
スポンサーリンク
概要
- 論文の詳細を見る
Although an increased expression of proinflammatory cytokines has been reported in cardiac tissue samples from patients with congestive heart failure (CHF) and in various animal models of CHF, the role of these cytokines in the disease remains to be determined. Dahl salt-sensitive (DS) rats fed a high salt diet develop hypertension, cardiac hypertrophy and eventually CHF. In the present study, DS rats were treated with FR167653 (1-[7-(4- fluoropheny1)-1,2,3,4-tetrahydro-8-(4-pyridy1)pyrazolo[5, l-c] [1,2,4]triazin-2-y1]-2-phenylethanedione sulfate monohydrate), a new low molecular weight inflammatory cytokine inhibitor. Treatment with 10mg/kg per day of FR167653 significantly prolonged the survival of the animals and also prevented the bodyweight loss associated ated with heart failure. In conclusion, a non-peptide proinflammatory cytokine inhibitor improved the survival of animals with heart failure. (Jpn Circ J 2001; 65: 584-585)
- 2001-05-20
著者
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Kihara Yasuki
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Science
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Shioi Tetsuo
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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Matsumori Akira
同志社大学 生命医科学部
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Matsumori Akira
Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine
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Sasayama S
Department Of Life And Medical Science Doshisha University Kyotanabe & Daijukai Hospital
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Sasayama Shigetake
浜松労災病院
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Matsumori A
Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine
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Shioi Tetsuo
Department Of Cardiology And Internal Medicine Kitasato University School Of Medicine
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Sasayama Shigetake
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
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Sasayama Shigetake
The Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
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Sasayama Shigetake
Department Of Life And Medical Science Doshisha University Kyotanabe & Daijukai Hospital
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Saijyo Sayaka
Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
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KAKIO Tadashi
Department of Cardiology, Hamamatsu Rosai Hospital
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Sawada Shigeo
Department Of Cardiology Doshisha University
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Sasayama Shigetake
The Third Division Of Medicine Kyoto University
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Sasayama Shigetake
Hamamatsu Rosai Hospital
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Kihara Yasuki
Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine
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Kihara Yasuki
Department Of Cardiology Graduate School Of Medicine Kyoto University
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Marui Akira
Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine
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Sasayama Shigetake
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Sasayama Shigetake
Division Of Medicine Hamamatsu Rosai Hospital Shizuoka
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Sasayama Shigetake
Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
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Kakio Tadashi
Department Of Cardiology Hamamatsu Rosai Hospital
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Sasayama Shigetake
Department Of Cardiology Doshisha University
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Matsumori Akira
Department Of Cardiology Kyoto University
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Saijyo Sayaka
The Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
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Murashige Akihiro
Department Of Cardiology Kyoto University
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Matsumori A
The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Matsumori Akira
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Sasayama Shigetake
Department Of Cardiovascular Medicine Graduate School Of Medicine
-
Saijo Sayaka
Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
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Kihara Yasuki
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
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