Pericardial Fluid From Patients With Ischemic Heart Disease Accelerates the Growth of Human Vascular Smooth Muscle Cells
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概要
- 論文の詳細を見る
The strong association between severe coronary stenosis and collateral growth continues to be a paradigm in this field of investigation. The present study was based on the hypothesis that angiogenic growth factors are produced by ischemic cardiac tissue, are diffusible and more concentrated in pericardial fluid, and accelerate the growth of vascular smooth muscle cells (VSMC). Pericardial fluid from 17 patients with stable or unstable angina or acute myocardial infarction (group A) and from 10 patients with nonischemic heart disease (group B) were collected at the time of open heart surgery. Cultured human aortic VSMC were plated at the third passage at a density of 5×10^3/100μl and allowed to attach for 24h. The 3-day growth assay was preceded by 72h of growth arrest with 0.4% fetal calf serum (FCS). Growth was restarted by the addition of 90μl of medium containing 0.4% FCS, and 10μl of each pericardial fluid. Cell counts on triplicate wells were performed using a dimethylthiazol (MTT) method on days 0 and 3. The effect of pericardial fluid on the growth of VSMC was evaluated as a ratio (R) of cell numbers on day 3 to those on day 0. The concentration of basic fibroblast growth factor (bFGF) in pericardial fluid was measured by an enzyme-linked immunosorbent assay. The concentration of bFGF in pericardial fluid of group A was 633±127pg/ml, and significantly (p=0.003) higher than that of group B (86±23pg/ml). R in group A was 2.29±0.18 and significantly (p=0.019) higher than that in group B (1.68±0.11). The level of bFGF positively correlated with R (p=0.009). These findings indicate that pericardial fluid from patients with ischemic heart disease contains some substances that mediate collateral development, and bFGF might be one of them.
- 社団法人日本循環器学会の論文
- 2000-06-20
著者
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Kihara Yasuki
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Science
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Sawamura Tatsuya
Department of Bioscience, National Cardiovascular Center Research Institute
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Fujita M
Human Health Sciences Graduate School Of Medicine Kyoto University
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Sasayama S
Department Of Life And Medical Science Doshisha University Kyotanabe & Daijukai Hospital
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Sasayama Shigetake
浜松労災病院
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Nohara Ryuji
Department of Cardiology, Kitano Hosptal
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Hasegawa Koji
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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Sasayama Shigetake
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
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Sasayama Shigetake
The Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
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Hasegawa Koji
Division Of Translational Research Kyoto Medical Center National Hospital Organization
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Fujita Masatoshi
College of Medical Technology, Kyoto University
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Yamada Takehiko
Department Of Cardiology Daio Municipal Hospital
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Nohara R
Division Of Cardiology Kitano Hospital
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Nohara Ryuji
Department Of Cardiology Clinical Sciences For Pathological Organs Graduate School Of Medicine Kyoto
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Saijyo Sayaka
Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
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Hasegawa Koji
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Yoneda Takeshi
Department of Cardiovascular Medicine, Graduate School of Medicine
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Tanaka Terumitsu
Division of Cardiology, Takeda Hospital
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Inanami Miyako
College of Medical Technology, Kyoto University
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Sawada Shigeo
Department Of Cardiology Doshisha University
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Sasayama Shigetake
The Third Division Of Medicine Kyoto University
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Fujita Masatoshi
College Of Medical Technology Kyoto University
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Kihara Yasuki
Department Of Cardiology Graduate School Of Medicine Kyoto University
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Nohara Ryuji
Third Division Department Of Internal Medicine Kyoto University Faculty Of Medicine
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Kihara Yasuki
Department Of Cardiovascular Medicine Graduate School Of Medicine
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Sasayama Shigetake
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Sasayama Shigetake
Division Of Medicine Hamamatsu Rosai Hospital Shizuoka
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Yamada Takehiko
Department Of Cardiovascular Medicine Graduate School Of Medicine
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Yoneda Takeshi
Department Of Cardiology Shizuoka City Hospital
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Inanami Miyako
College Of Medical Technology Kyoto University
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Sasayama Shigetake
Department Of Cardiology Doshisha University
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Saijyo Sayaka
The Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
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Tanaka Terumitsu
Division Of Cardiology Takeda Hospital
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Sawamura Tatsuya
Department Of Vascular Physiology National Cardiovascular Center Research Institute
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Sawamura Tatsuya
Department Of Vascular Physiology National Cardiovascular Center
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Sawamura Tatsuya
Department Of Bioscience National Cardiovascuar Center Reserch Institute
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Nohara Ryuji
Division Of Cardiovascular Medicine Kyoto University
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Hasegawa Koji
Department Of Biology College Of Liberal Arts Kagoshima University
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Sasayama Shigetake
Department Of Cardiovascular Medicine Graduate School Of Medicine
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Hasegawa Koji
Department Of Applied Chemistry Nagoya Institute Of Technology
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Nohara Ryuji
Kyoto Univ. Hospital
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