Inhomogeneity in the Appearance of Electrical Remodeling During Chronic Rapid Atrial Pacing : Evaluation of the Dispersion of Atrial Effective Refractoriness
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概要
- 論文の詳細を見る
In the present study, the long-term process of progression of electrical remodeling at various atrial sites, which is not well understood, was compared while monitoring continuously the electrophysiologic parameters at multirecording sites in canine atria during continuous atrial burst pacing. A rapid pacing device was implanted in 5 dogs, and continuous atrial burst pacing (400beats/min) was delivered at the right atrial appendage (RAA). Four pairs of epicardial wire electrodes were sutured on (1) the RAA, (2) Bachmann's bundle (BB), (3) the right atrium close to the inferior vena cave (IVC), and (4) the left atrium (LA). The distal ends of those wires were exteriorized posteriorly and used for pacing and recording. The atrial effective refractory period (AERP), AERP dispersion (AERPd), atrial conduction time (CT) and inducibility of atrial fibrillation (AF) were evaluated during burst pacing for 14 days and during the subsequent 7 days' recovery. The AERP at the LA pacing site was shorter than that at the other sites on day 0. The AERP shortening was greater in the RAA and LA sites than in the BB and IVC sites. The AERPd increased during pacing and reached the maximum level on day 3, and then decreased during the recovery phase. Prolongation of CT tended to be longer between the RAAand IVC sites than that between the other sites. The incidence of AF induction became higher in accordance with the time course of the rapid pacing phase. There was another peak of AF induction on days 7-10. In a canine chronic rapid atrial stimulation model, the progression of electrical remodeling (ie, the shortening of the AERP and the prolongation of the CT) was not homogeneous in both atria, the AERPd showed a temporal increase between days 3 and 7 and matched the increase in AF inducibility at the LA pacing site, the increase in the AERPd was mainly caused by more rapid AERP shortening at the RAA or LA sites, and the LA site always showed a shorter AERP than the other atrial sites in the control state and during the rapid pacing phase, whereas AF inducibility was higher at the LA site than the other sites.
- 社団法人日本循環器学会の論文
- 2001-03-20
著者
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Izumi Tohru
Department Of Cardio-angiology Kitasato University School Of Medicine
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NIWANO Shinichi
Department of Cardio-Angiology, Kitasato University School of Medicine
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MORIGUCHI Masahiko
Department of Cardio-Angiology, Kitasato University School of Medicine
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Izumi Tohru
北里大学 医学部循環器内科
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Kojima Jisho
Department of Cardio-angiology, Kitasato University School of Medicine
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Moriguchi Masahiko
北里大学 医学部循環器内科学
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Moriguchi Masahiko
Department Of Cardio-angiology Kitasato University School Of Medicine
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Moriguchi Masahiko
Department Of Internal Medicine/cardiology Kitasato University School Of Medicine
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Kojima Jisho
北里大学 医学部循環器内科学
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Kojima Jisho
Department Of Cardio-angiology Kitasato University School Of Medicine
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Niwano Shinichi
Department Of Cardio-angiology Kitasato University School Of Medicine
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Niwano Shinichi
日本不整脈学会
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Inuo Kimiatsu
Department of internal Medicine,Kitasato University School of Medicine
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Yoshizawa Naoto
Department of Cardiovascular Medicine, Kitasato University Graduate School of Medicine
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Kitano Yoshikazu
Department of Cardiovascular Medicine, Kitasato University Graduate School of Medicine
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Saitou Junko
Department of Internal Medicine, Kitasato University School of Medicine
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Yoshizawa Naoto
Department Of Internal Medicine Kitasato University School Of Medicine
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Kitano Yoshikazu
Department Of Internal Medicine
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Kitano Yoshikazu
Department Of Applied Biological Science Tokyo Noko University
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Miwano Shinichi
北里大学
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Kojima Jisyo
Department Of Internal Medicine Kitasato University School Of Medicine
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Inuo Kimiatsu
北里大学 内科学
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Inuo Kimiatsu
Department Of Internal Medicine Kitasato University School Of Medicine
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Saitou Junko
Department Of Internal Medicine Kitasato University School Of Medicine
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Niwano Shinichi
北里大学 医学部循環器内科学
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Niwano Shinichi
Department Of Cardio-angiology Kitasato University
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Izumi Tohru
Department Of Cardio-angiology Kitasato University School Of Medcine
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Kojima Jisho
Department Of Internal Medicine Kitasato University School Of Medicine
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Izumi Tohru
Department Of Angio-cardiology Kitasato University School Of Medicine
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NIWANO Shinichi
Department of Cardio-andiology, Kitasato University School of Medicine
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Niwano Shinichi
Department of Angio-Cardiology, Kitasato University School of Medicine
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