A Long Course of Leukocytopenia and Splenomegaly with Extramedullary Hematopoiesis in the Absence of Clinically Manifested Rheumatoid Arthritis
スポンサーリンク
概要
- 論文の詳細を見る
A 70-year-old female with a long history of progressive leukocytopenia and giant splenomegaly is described. She had no clinically manifested rheumatoid arthritis, although she complained of slight arthralgia in the digital joints, wrists and ankles at irregular intervals. Repeated bone marrow aspirations showed no cellular atypism, chromosomal abnormalities, or phenotypical abnormalities. Just before splenectomy, both anti-neutrophil antibody positivity and anti-cyclic citrullinated peptide antibody positivity were shown. Histology of the splenectomized spleen showed follicular hyperplasia with plasmacyte infiltration and extramedullary hematopoeisis. After splenectomy, leukocyte counts returned to normal with normal leukocyte differentials and anti-neutrophil antibodies disappeared. She was almost free of arthralgia one year after splenectomy, although the anti-cyclic citrullinated peptide antibody titers remained high.
- 日本リンパ網内系学会の論文
- 2010-11-01
著者
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SATO Kazuya
Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical Coll
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Izumi Tohru
Department Of Cardio-angiology Kitasato University School Of Medicine
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Tanaka Akira
Department of Health and Nutrition, College of Human and Environmental Studies, Kanto-Gakuin Univers
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Ozawa Keiya
Division of Genetic Therapeutics, Jichi Medical School
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Muroi Kazuo
Division of Cell Transplantation and Transfusion, Jichi Medical School
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Izumi T
The Department Of Hematology
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Muroi Kazuo
Division Of Hematology Department Of Medicine Jichi Medical University
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Muroi Kazuo
The Department Of Hematology
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Muroi Kazuo
Division Of Cell Transplantation And Transfusion Jichi Medical School
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Ozawa K
Division Of Genetic Therapeutics Center For Molecular Medicine Jichi Medical University
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Ozawa Keiyo
Department Of Hematology Jichi Medical School
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Sato Kazuya
Division Of Gastroenterology And Hematology/oncology Department Of Medicine Asahikawa Medical Colleg
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Sato Kazuya
Division Of Hematology Department Of Medicine Jichi Medical University
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Izumi Tohru
Research And Development Division Kikkoman Corporation
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Ozawa K
Division Of Hematology Department Of Medicine Jichi Medical University
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Izumi Tohru
Department Of Cardiology And Internal Medicine Kitasato University
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Ozawa Keiya
Division Of Genetic Therapeutics Center For Molecular Medicine Jichi Medical School Crest Japan Scie
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Izumi Tohru
Department Of Cardio-angiology Kitasato University School Of Medcine
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SAKUMA Yasunaru
Department of Surgery, Jichi Medical University
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Ozawa Keiya
Division Of Genetic Therapeutics Center For Molecular Medicine Department Of Medicine Jichi Medical
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Sakuma Yasunaru
Department Of Surgery Jichi Medical University
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Tanaka Akira
Department Of Diagnostic Pathology Jichi Medical University
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Ozawa Keiya
Division Of Genetic Therapeutics Center For Molecular Medicine
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Izumi Tohru
Department Of Angio-cardiology Kitasato University School Of Medicine
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Muroi Kazuo
Division of Cell Therapy, Jichi Medical University Hospital
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TANAKA Akira
Department of Agricultural Chemistry, Faculty of Agriculture, Tohoku University
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Ozawa Keiya
Division of Cell Therapy, Jichi Medical University Hospital, Shimotsuke
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