Evaluation of Post-Repolarization Refractoriness for Conduction Block in Cardiac Muscle : Studies in an Artificial Isthmus in the Canine Right Atrium
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概要
- 論文の詳細を見る
Post-repolarization refractoriness(PRR) is an important factor in determining conduction block and is the difference between the effective refractory period(ERP) and the duration of the monophasic action potential(MAPD). In the present study, conduction block in an artificial isthmus in the canine atrium was evaluated and the coupling interval of a premature beat, which caused the block, was defined as the block coupling interval(BCI). The usefulness of this value was also evaluated. Radiofrequency linear ablation was performed on the right atrial surface parallel to the atrioventricular groove in 5 mongrel dogs, and an artificial isthmus (8-10 mm wide and 25-30 mm long) was created. Fourteen simultaneous unipolar recordings were performed in the isthmus with a resolution of 1.2 mm. Single extra-stimuli with basic drive train were delivered to induce conduction block in the isthmus and when it occurred, the coupling interval at the recording site just proximal to the site of the block was defined as the BCI. At the site of the block, the ERP and MAPD at each drive cycle length were measured. The PRR was calculated using 2 different formulae: (1) [ERP-MAPD], and (2) [BCI-MAPD]. It was found that each value was shortened in accordance with the shortening of the basic drive cycle length. In all basic drive trains, BCI>ERP>MAPD, and [ERP-MAPD] was always shorter than [BCI-MAPD]. In the shorter cycle length of basic drives, the difference between [ERP-MAPD] and [BCI-MAPD] was more prominent. In the artificial isthmus model in the canine atrium, BCI was always longer than the ERP measured at the same site as the block. Because the ERP may not directly reflect the block phenomenon, the electrophysiologic evaluation should use the BCI instead, as in the PRR evaluation.
- 社団法人日本循環器学会の論文
- 2000-12-20
著者
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Izumi Tohru
Department Of Cardio-angiology Kitasato University School Of Medicine
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MORIGUCHI Masahiko
Department of Cardio-Angiology, Kitasato University School of Medicine
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Izumi Tohru
北里大学 医学部循環器内科
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SAITO Junko
Department of Obstetrics and Gynecology, Osaka University Medical School
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Moriguchi Masahiko
北里大学 医学部循環器内科学
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Moriguchi Masahiko
Department Of Cardio-angiology Kitasato University School Of Medicine
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Moriguchi Masahiko
Department Of Internal Medicine/cardiology Kitasato University School Of Medicine
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Niwano Shinichi
Department Of Cardio-angiology Kitasato University School Of Medicine
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Niwano Shinichi
日本不整脈学会
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Inuo Kimiatsu
Department of internal Medicine,Kitasato University School of Medicine
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Yoshizawa Naoto
Department of Cardiovascular Medicine, Kitasato University Graduate School of Medicine
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Kitano Yoshikazu
Department of Cardiovascular Medicine, Kitasato University Graduate School of Medicine
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Yoshizawa Naoto
Department Of Internal Medicine Kitasato University School Of Medicine
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Kitano Yoshikazu
Department Of Internal Medicine
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Kitano Yoshikazu
Department Of Applied Biological Science Tokyo Noko University
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Miwano Shinichi
北里大学
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Inuo Kimiatsu
北里大学 内科学
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Inuo Kimiatsu
Department Of Internal Medicine Kitasato University School Of Medicine
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Saitou Junko
Department Of Internal Medicine Kitasato University School Of Medicine
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Saito Junko
Department Of Biology Faculty Of Education Yamanashi University
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Niwano Shinichi
北里大学 医学部循環器内科学
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Niwano Shinichi
Department Of Cardio-angiology Kitasato University
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Izumi Tohru
Department Of Cardio-angiology Kitasato University School Of Medcine
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Izumi Tohru
Department Of Angio-cardiology Kitasato University School Of Medicine
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NIWANO Shinichi
Department of Cardio-andiology, Kitasato University School of Medicine
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Niwano Shinichi
Department of Angio-Cardiology, Kitasato University School of Medicine
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