Advantage of Recombinant Technology for the Identification of Cardiac Myosin Epitope of Severe Autoimmune Myocarditis in Lewis Rats
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概要
- 論文の詳細を見る
Whole cardiac myosin induced experimental autoimmune myocarditis (EAM) in animals. The identification of the epitope causing EAM is expected to elucidate the mechanism leading to the onset of this autoimmune disease. Until now such studies have been done mostly with synthetic oligo-peptides. We employed recombinant technology to produce the immunogenic fragment of the self-cardiac myosin heavy chain (CMHC) for EAM in Lewis rats, and successfully induced severe myocarditis with short recombinant peptide fragment CMHC residues 1107 to 1186. The immunogenicity was completely abolished from the fragment with futher excision of 12 amino acids from residues 1131 to 1143. This recombinant technology clearly has advantages in the ease of manipulation and the purity for the creation of immunogenic epitopes. (Jpn Heart J 2000; 41: 67-77)
- Japanese Heart Journal Associationの論文
著者
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Izumi Tohru
Department Of Cardio-angiology Kitasato University School Of Medicine
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Izumi Tohru
北里大学
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KOHNO Ken
Department of Internal Medicine and Cardiology, Kitasato University School of Medicine, Kanagawa, Ja
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TAKAGAKI Yohtaroh
Department of Internal Medicine and Molecullar Biology, Kitasato University School of Medicine, Kana
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NAKAJIMA Yoichi
Department of Internal Medicine and Molecullar Biology, Kitasato University School of Medicine, Kana
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Takagaki Yohtaroh
Department Of Internal Medicine And Cardiology And Gene Genetcs Kitasato University School Of Medici
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Nakajima Yoichi
Department Of Earth Sciences Waseda University
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Kohno Ken
Department Of Cardio-angiology Kitasato University School Of Medicine
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Izumi Tohru
Department Of Angio-cardiology Kitasato University School Of Medicine
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KOHNO Ken
Department of Internal Medicine and Cardiology, Kitasato University School of Medicine, Kanagawa, Japan.
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TAKAGAKI Yohtaroh
Department of Internal Medicine and Molecullar Biology, Kitasato University School of Medicine, Kanagawa, Japan.
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IZUMI Tohru
Department of Internal Medicine and Cardiology, Kitasato University School of Medicine, Kanagawa, Japan.
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