Clinical Usefulness of Electrophysiologic Study (EPS)-Guided Risk Stratification for Life-Threatening Arrhythmia in Patients With Heart Failure
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概要
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Background: Ventricular tachyarrhythmia is one of the most important factors determining the prognosis of patients with heart failure and sudden death can be observed even during stable therapy controlling clinical heart failure. In this study, the usefulness of electrophysiologic study (EPS) for the prediction of a future arrhythmic event was evaluated in patients with heart failure. Methods and Results: The patient population consisted of 474 patients with a history of clinical heart failure but without an episode of spontaneous sustained ventricular tachycardia or fibrillation (VT/VF). A Holter ECG was performed in all patients, and 177 of the 474 patients underwent EPS because of a recording of nonsustained VT (NSVT, > 5 beats). When sustained VT/VF was inducible in EPS, the patient was assigned to implantation of a defibrillation device. The patients were divided into 3 groups, ie, 1) no NSVT (n = 297), 2) NSVT + no inducible VT/VF (n = 134), and 3) NSVT + inducible VT/VF (n = 43), and were followed-up for > 12 months. All patients were followed-up under standard therapy for heart failure. There were no significant differences in basic clinical characteristics and therapies among the 3 groups. During the follow-up period of 32 ± 18 months, 56/474 patients suffered a VT/VF episode, ie, 21/297 in no NSVT, 14/134 in NSVT + no inducible VT/VF, and 21/43 in NSVT + inducible VT/VF patients (P = 0.032). All patients were rescued from sudden death among patients with an implanted defibrillator, but 11 patients without a defibrillator died. Conclusion: In patients with heart failure, future arrhythmic events could be predicted by EPS and Holter ECG. EPS-guided risk stratification seems to be useful in managing patients with heart failure.
- インターナショナル・ハート・ジャーナル刊行会の論文
著者
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Izumi Tohru
Department Of Cardio-angiology Kitasato University School Of Medicine
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NIWANO Shinichi
Department of Cardio-Angiology, Kitasato University School of Medicine
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Fukaya Hidehira
Department of Cardio-angiology, Kitasato University School of Medicine
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Fukaya Hidehira
北里大学 医学部循環器内科学
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Niwano Shinichi
Department Of Cardio-angiology Kitasato University School Of Medicine
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Sasaki Sae
Department of Cardio-angiology, Kitasato University School of Medicine
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Yuge Masaru
Department of Cardio-angiology, Kitasato University School of Medicine
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Imaki Ryuta
Department of Cardio-angiology, Kitasato University School of Medicine
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Inomata Takayuki
Department of Cardio-angiology, Kitasato University School of Medicine
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Inomata Takayuki
Department Of Cardio-angiology Kitasato University School Of Medicine
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Imaki Ryuta
Department Of Cardio-angiology Kitasato University School Of Medicine
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Yuge Masaru
Department Of Cardio-angiology Kitasato University School Of Medicine
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Sasaki Sae
Department Of Cardio-angiology Kitasato University School Of Medicine
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Imaki Ryuta
Department Of Angio-cardiology Kitasato University School Of Medicine
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Izumi Tohru
Department Of Angio-cardiology Kitasato University School Of Medicine
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NIWANO Shinichi
Department of Cardio-andiology, Kitasato University School of Medicine
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Fukaya Hidehira
Department of Angio-Cardiology, Kitasato University School of Medicine
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Niwano Shinichi
Department of Angio-Cardiology, Kitasato University School of Medicine
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Yuge Masaru
Department of Angio-Cardiology, Kitasato University School of Medicine
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