Bepridil Inhibits Sub-Acute Phase of Atrial Electrical Remodeling in Canine Rapid Atrial Stimulation Model

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Background The effect of bepridil, a multichannel blocker, on atrial electrical remodeling was evaluated in a canine rapid atrial stimulation model. Methods and Results In 10 beagle dogs, the right atrial appendage (RAA) was paced at 400beats/min for 2 weeks. The atrial electrophysiological parameters, including effective refractory period (AERP), were evaluated at three atrial sites : RAA, the right atrium close to the inferior vena cava (IVC) and the left atrium (LA), during the time course of rapid pacing. Five of the dogs were given bepridil (10mg・kg^<-1>・day^<-1> po). In the control group, AERP was significantly shortened at all atrial sites and the AERP shortening (ΔAERP) was larger for the RAA and LA than at the IVC site (p<0.05). In the bepridil group, ΔAERP was smaller than that of the controls at all atrial sites, and the AERP started to return slowly to the pre-pacing level in the second week, regardless of the continuation of rapid pacing. Conclusions In a canine rapid atrial stimulation model, bepridil suppressed AERP shortening. Bepridil might have a reverse electrical remodeling effect, at least for AERP shortening, because it showed slow recovery of AERP in the subacute phase of rapid atrial pacing.
社団法人日本循環器学会の論文
2006-01-20