Human parvovirus B19 and rheumatoid arthritis

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Human parvovirus B19 （B19） is single stranded DNA virus, that causes erythema infectinosum in infantand/or acute onset polyarthritis in adult. We present the evidence showing the role of B19 on the etiopathogy ofrheumatoid arthritis（ RA）.（ 1） B19 DNA could be frequently amplifi ed in the samples from rheumatoid joints. Thedetection B19 RNA and B19 protein VP1 was specific for RA, and positive at T cells, B cells, macrophages andfollicular dendritic cells in rheumatoid synovium. （ 2） B19 infection or transduction of B19 NS1gene caused TNFα,IL-6 and IL-8 production through activating AP1 and AP2 in macrophages or macrophage celll line U937. We alsofound Ku80 as a novel receptor for B19 on T cells, macrophages or erythroblasts. B19 used clathrin on the surface attheir cell entry and caused enhanced actin polymerization, resulting in the migration of T cells. （ 3） B19-transgenicmice became susceptible to type II collagen-induced polyarthritis that is a model of RA. We also experienced 12cases who developed RA after acute B19 infection. （ 4） Half of RA cases had a defective neutralizing ability to B19.
弘前大学の論文