Mesenchymal Stromal Cells for Graft-Versus-Host Disease : Basic Aspects and Clinical Outcomes

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概要

• 論文の詳細を見る

• Mesenchymal stromal cells (MSCs) have unique characteristics such immune suppression by inhibiting T cell proliferation, tissue-repair ability and acceleration of hemopoietic stem cell engraftment. The cells are rare in bone marrow, but easily cultured under standard culture conditions. Soluble factors and cells are implicated in the MSC-mediated T cell suppression and numerous clinical trials using MSCs to prevent and treat graft-versus-host disease (GVHD) have been reported. MSCs are suggested to suppress acute GVHD without impairing graft-versus-leukemia effects and increasing systemic infections. In this review, we focus on basic aspects of MSC-mediated T cell suppression and clinical trials using MSCs for GVHD and related conditions.

• 日本リンパ網内系学会の論文
• 2010-11-01

著者

• Mori Masaki

  Division of Gene Therapy Science, Osaka University Graduate School of Medicine

• SATO Kazuya

  Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical Coll

• Ozawa Keiya

  Division of Genetic Therapeutics, Jichi Medical School

• Muroi Kazuo

  Division of Cell Transplantation and Transfusion, Jichi Medical School

• Muroi Kazuo

  Division Of Hematology Department Of Medicine Jichi Medical University

• Muroi Kazuo

  Division Of Cell Transplantation And Transfusion Jichi Medical School

• Ozawa K

  Division Of Genetic Therapeutics Center For Molecular Medicine Jichi Medical University

• Ozawa Keiyo

  Department Of Hematology Jichi Medical School

• Mori Masaki

  Division Of Hematology Department Of Medicine Jichi Medical University

• Sato Kazuya

  Division Of Gastroenterology And Hematology/oncology Department Of Medicine Asahikawa Medical Colleg

• Sato Kazuya

  Division Of Hematology Department Of Medicine Jichi Medical University

• OZAKI Katsutoshi

  Division of Hematology, Department of Medicine, Jichi Medical University

• Ozawa K

  Division Of Hematology Department Of Medicine Jichi Medical University

• Mori Masaki

  Division Of Gene Therapy Science Osaka University

• Ozawa Keiya

  Division Of Genetic Therapeutics Center For Molecular Medicine Jichi Medical School Crest Japan Scie

• Ozaki Katsutoshi

  Division Of Hematology Department Of Medicine Jichi Medical University

• Ozawa Keiya

  Division Of Genetic Therapeutics Center For Molecular Medicine Department Of Medicine Jichi Medical

• Ozawa Keiya

  Division Of Genetic Therapeutics Center For Molecular Medicine

• MORI Masaki

  Division of Cell Therapy, Jichi Medical University Hospital

• OZAKI Katsutoshi

  Division of Cell Therapy, Jichi Medical University Hospital

• Muroi Kazuo

  Division of Cell Therapy, Jichi Medical University Hospital

• Ozawa Keiya

  Division of Cell Therapy, Jichi Medical University Hospital, Shimotsuke

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