Successful Treatment of a Patient with Rheumatoid Arthritis and IgA-Kappa Multiple Myeloma with Tocilizumab
スポンサーリンク
概要
- 論文の詳細を見る
A 63-year-old woman receiving tumor necrosis factor (TNF) inhibitors for rheumatoid arthritis (RA) was found to have smoldering IgA-kappa type multiple myeloma (MM). Retrospective examination of stored serum samples revealed a steady increase of serum IgA levels after the start of TNF inhibitor therapy. The patients articular symptoms showed marked exacerbation when TNF inhibitors were discontinued because of fear of worsening the MM. Tocilizumab improved RA symptoms dramatically and stabilized serum IgA levels for 13 months after a transient steep rise. This case suggests that tocilizumab can be used safely in patients with inflammatory disorders with coexisting MM.
著者
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Iwamoto Masahiro
Division Of Rheumatology And Clinical Immunology Department Of Medicine Jichi Medical University
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Sato Kazuya
Division Of Gastroenterology And Hematology/oncology Department Of Medicine Asahikawa Medical Colleg
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Minota Seiji
Division Of Rheumatology And Clinical Immunology Department Of Internal Medicine Jichi Medical Schoo
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Kamata Yasuyuki
Division Of Rheumatology And Clinical Immunology Jichi Medical School
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Nagashima Takao
Division Of Rheumatology And Clinical Immunology Department Of Medicine Jichi Medical School
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Okazaki Hitoaki
Division Of Clinical Immunology And Rheumatology Department Of Medicine Jichi Medical School School
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Ozawa Keiya
Division of Cell Therapy, Jichi Medical University Hospital, Shimotsuke
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Matsuyama Yasushi
Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical University, Japan
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Honne Kyoko
Division of Rheumatology and Clinical Immunology, Jichi Medical University, Japan
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Minota Seiji
Division of Rheumatology and Clinical Immunology, Jichi Medical University, Japan
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Kamata Yasuyuki
Division of Rheumatology and Clinical Immunology, Jichi Medical University, Japan
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