Safe And Efficient Collection of Cytokine-Mobilized Peripheral Blood Cells From Cynomolgus Monkeys (Macaca fascicularis) with Human Newborn-Equivalent Body Weights
スポンサーリンク
概要
- 論文の詳細を見る
Hematopoietic stem cells in bone marrow can be mobilized into peripheral blood by cytokine administration. Cytokine-mobilized peripheral blood stem cells are of great use in clinical applications. We previously established a modified procedure for the collection of cytokine-mobilized peripheral blood cells from rhesus monkeys (Macaca mulata) using a commercially available apparatus originally developed for human subjects. In this study, we examined the efficacy and safety of this method with even smaller macaques, cynomolgus monkeys (Macaca fascicularis), which are equivalent to human newborns in body weight (mean = 3.3 kg). Using the manufacturers unmodified protocol (n=6), one monkey died of cardiac failure and three developed severe anemia. In contrast, using our modified procedure (n=6), no such complication was observed in any animal. In addition, the harvested nuclear cell, mononuclear cell and CD34+ cell counts were significantly higher with the modified method. The modified method should allow safe and efficient collection of cytokine-mobilized peripheral blood cells from non-human primates as small as human newborns in a non-invasive manner.
- 社団法人 日本実験動物学会の論文
- 2005-10-01
著者
-
YOSHIKAWA Yasuhiro
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University
-
Ageyama Naohide
Tsukuba Primate Center, National Institute of Infectious Diseases
-
Shibata Hiroaki
Tsukuba Primate Center, National Institute of Infectious Diseases
-
Terao Keiji
Tsukuba Primate Center, National Institute of Infectious Diseases
-
ONO Fumiko
Corporation for Production and Research of Laboratory Primates
-
Yoshikawa Y
Department Of Biomedical Science The Graduate School Of Agricultural And Life Sciences The Universit
-
Ozawa K
Division Of Genetic Therapeutics Center For Molecular Medicine Jichi Medical University
-
Ozawa K
Jichi Medical School Tochigi Jpn
-
Ozawa Keiyo
Department Of Hematology Jichi Medical School
-
HASEGAWA Mamoru
DNAVEC Corporation
-
Ageyama Naohide
Tsukuba Primate Center National Institute Of Infectious Diseases
-
Ageyama Naohide
Tsukuba Primate Center For Medical Science National Institute Of Infectious Diseases
-
HANAZONO Yutaka
Center for Molecular Medicine, Jichi Medical School
-
OGAWA Hiromi
Corporation for Production and Research of Laboratory Primates
-
NAGASHIMA Takeyuki
DNAVEC Corporation
-
UEDA Yasuji
DNAVEC Corporation
-
OZAWA Keiya
Center for Molecular Medicine, Jichi Medical School
-
NAGASHIMA TAKEYUKI
University of Tsukuba
-
Shibata Hiroaki
Tsukuba Primate Center National Institute Of Infectious Diseases
-
Yoshikawa Yasuhiro
Department Of Biomedical Science The Graduate School Of Agricultural And Life Sciences The Universit
-
Yoshikawa Yasuhiro
Department Of Biomedical Science Faculty Of Agriculture The University Of Tokyo
-
Terao Keiji
Tsukuba Primate Center National Institute Of Infectious Diseases
-
Terao Keiji
Tsukuba Primate Center For Medi.sci. Nation.inst.health
-
Ono F
Univ. Tokyo Chiba Jpn
-
Ono Fumiko
Tsukuba Primate Center For Medical Science National Institute Of Infectious Diseases
-
Ueda Yasuji
Dnavec Research. Inc.
-
Hasegawa Mamoru
Dnavec Research. Inc.
-
Hasegawa Mamoru
Dnavec Research Inc.
-
Shibata H
Tsukuba Primate Center National Institute Of Infectious Diseases
-
Ozawa K
Division Of Hematology Department Of Medicine Jichi Medical University
-
Hanazono Y
Division Of Regenerative Medicine Jichi Medical School
-
Okada Koji
Division Of Genetic Therapeutics Center For Molecular Medicine Department Of Medicine Jichi Medical
-
Okada Koji
Division Of Genetic Therapeutics Jichi Medical School
-
Ono Fumiko
Corp. Production And Res. Lab. Primates Tsukuba Jpn
-
Ozawa Keiya
Center For Molecular Medicine Jichi Medical School
-
Terao Keiji
Tsukuba Primate Research Center, National Institute of Biomedical Innovation
関連論文
- マウスノロウイルスS7株に対する特異抗体を検出するための間接ELISA法および間接蛍光抗体法
- Retroperitoneal Fibromatosis in a Cynomolgus Monkey (Macaca fascicularis)
- 老齢マカクサルにおける加齢性学習能力の減衰と海馬歯状回のニューロン新生との相関関係
- Thrombopoietin (TPO) regulates HIF-1α levels through generation of mitochondrial reactive oxygen species
- ストレプトゾトシン誘発糖尿病APAハムスターの大動脈における小胞体ストレス
- Astroglial responses against Aβ initially occur in cerebral primary cortical cultures : species differences between rat and cynomolgus monkey
- Immunohistochemical Analysis of Protein Gene Product 9.5, a Ubiquitin Carboxyl-terminal Hydrolase, during Placental and Embryonic Development in the Mouse
- Protective Effects of Probucol Treatment on Pancreatic β-cell Function of SZ-induced Diabetic APA Hamsters
- Characterization of the Testis in Congenitally Ubiquitin Carboxy-Terminal Hydrolase-1 (Uch-L1) Defective (gad) Mice
- Changes in mRNA Expression in Mouse Postnatal Cochlea by Differential Display Method
- The Effect of Probucol on Atherosclerosis in Streptozotocin-Induced Diabetic-Hyperlipidemic APA Hamsters in Different Stages of Atherosclerosis
- PJ-369 Few Transplanted Bone Marrow CD34^+ Cells Become Endothelial and Myocardial Cells in Ischemic Myocardium in Nonhuman Primates(Angiogenesis 3 (IHD) : PJ62)(Poster Session (Japanese))
- Histopathological Studies of Aortic Dissection in Streptozotocin-Induced Diabetic APA Hamsters
- Presenilin-2 in the cynomolgus monkey brain : investigation of age-related changes
- Comparative Study on Toxicokinetics of Bisphenol A in F344 Rats, Monkeys (Macaca fascicularis), and Chimpanzees (Pan troglodytes)
- Molecular Evolution Inferred from Immunological Cross-reactivity of Immunoglobulin G among Chiroptera and Closely Related Species
- Spontaneous T-cell-rich B-cell Lymphoma in a Cynomolgus Monkey (Macaca fascicularis)
- Squamous Cell Carinoma of the Oral Cavity in an Infant Cynomolgus Monkey
- Ratio of Leptin to Adiponectin as an Obesity Index of Cynomolgus Monkeys : Macaca Fascicularis
- Relationship between Body Weight and Hematological and Serum Biochemical Parameters in Female Cynomolgus Monkeys (Macaca fascicularis)
- Effects of Aging on Bone Mineral Content and Bone Biomarkers in Female Cynomolgus Monkeys
- The Region-Specific Functions of Two Ubiquitin C-Terminal Hydrolase Isozymes along the Epididymis
- No Regional Differences of Cytochrome P450 Expression in the Liver of Cynomolgus Monkeys (Macaca fascicularis)
- D-Galactosamine Induced Hepatocyte Apoptosis is Inhabited in vivo and in Cell Culture by a Calcium Calmodulin Antagonist, Chlorpromazine, and a Calcium Channel Blocker, Verapamil
- Renal Function Tests on Diabetes-Induced and Non-Induced APA Hamsters
- Analysis of cDNA Coding MHC Class II β Chain of The Chimpanzee (Pan troglodytes)
- Expression of Lipoprotein Receptors in the Aortic Walls of Diabetic APA hamsters
- Functional and Histochemical Analysis on Pancreatic lslets of APA Hamsters with SZ-Induced Hyperglycemia and Hyperlipidemia
- APA Hamster Model for Diabetic Atherosclerosis. 2. Analysis of Lipids and Lipoproteins
- Aortic Atheromatous Lesions Developed in APA Hamsters with Streptozotocin induced Diabetes: A New Animal Model for Diabetic Atherosclerosis. 1. Histopathological Studies
- Localization and Age-Related Changes in Cytochrome P450 Expression in APA Hamster Livers
- Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes
- Successful Retrograde Transport of Fluorescent Latex Nanospheres in the Cerebral Cortex of the Macaque Monkey
- Histopathology of Natural Ebola Virus Subtype Reston Infection in Cynomolgus Macaques during the Philippine Outbreak in 1996
- Chronological and Spatial Analysis of the 1996 Ebola Reston Virus Outbreak in a Monkey Breeding Facility in the Philippines
- FRS-094 Systemic Interleukin-10 Expression Upregulates Heme Oxygenase-1 to Prevent Hypertension and Heart Failure in Dahl Salt-sensitive Rats(Heart Failure, Cardiac Remodeling and Cardiomyopathy 2, The 71st Annual Scientific Meeting of the Japanese Circul
- Adeno-associated Virus-mediated IL-10 Gene Transfer Prevents the Development of Hypertensive Heart Disease in Dahl Salt-sensitive Rats(Gene Therapy 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Adeno-associated Virus Vector-mediated Systemic Expression of Interleukin-10 Ameliorates Monocrotaline-induced Pulmonary Hypertension in Rats(Gene Therapy 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-223 Adeno-associated Virus-mediated IL-10 Gene Transfer Prevents the Development of Heart Failure(Heart Failure, Basic 2 (M) : PJ38)(Poster Session (Japanese))
- OJ-196 AAV-mediated IL-10-gene Transfer into Apolipoprotein E-deficient Mice Inhibits Atherosclerosis through Anti-inflammatory and Cholesterol-lowering Effects(Atherosclerosis, Basic 2 (IHD) : OJ22)(Oral Presentation (Japanese))
- Clinical features of adult acute leukemia with 11q23 abnormalities in Japan : a co-operative multicenter study
- Differences between BALB/c and C57BL/6 Mice in Mouse Hepatitis Virus Replication in Primary Hepatocyte Culture
- Sendai Virus Vecto-mediated Gene Transfer of Glial Cell Line-Derived Nertotrophic Factor Prevents Delayed Neuronal Death after Transient Global Ischemia in Gerbils
- A safety, pharmacokinetic and pharmacodynamic investigation of deferasirox (Exjade^【○!R】, ICL670) in patients with transfusion-dependent anemias and iron-overload : a Phase I study in Japan
- ユビキチンのC末端加水分解酵素欠損は骨石灰化を減少させる(生理学)
- Safe And Efficient Collection of Cytokine-Mobilized Peripheral Blood Cells From Cynomolgus Monkeys (Macaca fascicularis) with Human Newborn-Equivalent Body Weights
- Changes in mRNA Expression in Mouse Postnatal Cochlea by Differential Display Method
- Infection of an HIV-1/SIVmac Chimeric Virus Having HIV-1 env to Macaque Monkeys via the Vaginal Cavity
- PE-462 Interleukin-10 Enhances Lipid Quality with Increased Adiponectin Production in Adipogenic Visceral Stromal-vascular Cells(Growth factor/Cytokine-2 (H) PE77,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circ
- OE-194 Fluvastatin and Fenofibrate Increases Adiponectin Production in Adipogenic Visceral Stromal-vascular Cells(Metabolism/Biochemistry/Energetics-1 (H) OE33,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circ
- Hematopoietic stem cell gene therapy: a current overview
- Cryopreservation of Brain Tissue for Primary Culture
- Effective Delivery of a Lipophilic 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) into Rat Lymphoid Tissues
- Maintenance and preemptive therapy with ganciclovir for cytomegalovirus colitis with extremely high antigenemia in adult T-cell leukemia
- Sperm cryopreservation in patients with hematologic malignancies
- Active FKHRL1 overcomes imatinib resistance in chronic myelogenous leukemia-derived cell lines via the production of tumor necrosis factor-related apoptosis-inducing ligand
- Leuprorelin Acetate for Female Patients with Newly Diagnosed Acute Leukemia Receiving Chemotherapy
- L-Arginine Administration Reverses Anemia Associated with Renal Disease
- Reduction of CTLL-2 cytotoxicity by induction of apoptosis with a Fas-estrogen receptor chimera
- Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport
- Selective Expansion of Transduced Cells for Hematopoietic Stem Cell Gene Therapy
- Targeted Integration of Foreign DNA Into a Defined Locus on Chromosome 19 in K562 Cells Using AAV-Derived Components
- Efficacy of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) on an ARC/AIDS Rhesus macaque (Macaca mulatta) Infected with Simian Immunodeficiency Virus
- Interleukin-10 Prevents Atherogenesis through Inhibition of MCP-1 Expression and Correction of Lipoprotein Metabolism in Apo E-Deficient Mice
- Adeno-associated virus mediated gene transfer of IL-10 for inhibition of vascular inflammation
- Development of an Immunofluorescence Method for the Detection of Antibodies to Ebola Virus Subtype Reston by the Use of Recombinant Nucleoprotein-Expressing HeLa Cells
- INVESTIGATION OF THE MECHANISM OF DRUG-INDUCED AUTOIMMUNE HEMOLYTIC ANEMIA IN CYNOMOLGUS MONKEYS ELICITED BY A REPEATED-DOSE OF A HUMANIZED MONOCLONAL ANTIBODY DRUG
- Distribution of U5 Antigen on Lymphocyte Subsets in Human and Nonhuman Primates
- CD4 and CD8 expressions in African green monkey helper T lymphocytes: implication for resistance to SIV infection
- Transient Expression of CD20 Antigen(Pan B Cell Marker)in Activated Lymph Node T Cells
- Chromosome Sorting of Primates : Isolation and Identification of Y Chromosome in Green Monkeys
- Opportunistic Pneumocystis carinii Infection in Red-Bellied Tamarins (Saguinus Iabiatus)
- Possible Role of Genetic Factor(s) on Age-related Increase of Peripheral CD4^+CD^+8 Double Positive T Cells in Cynomolgus Monkeys
- Peripheral blood extrathymic CD4^+CD8^+ T cells with high cytotoxic activity are from the same lineage as CD^+CD8^- T cells in cynomolgus monkeys
- Age-Related Changes in Major Lymphocyte Subsets in Cynomolgus Monkeys
- Comparative Analysis of Human and Macaque Monkey CD4: Differences in Formaldehyde Lability and Conformation
- Peripheral blood CD4^+CD8^+ lymphocytes in cynomolgus monkeys are of resting memory T lineage
- Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis
- Horizontal Transmission of Toxoplasma gondii in Squirrel Monkeys (Saimiri sciureus)
- Molecular Cloning of ELOVL4 Gene from Cynomolgus Monkey (Masasa fascicularis)
- Upgrading of Flow Cytometric Analysis for Absolute Counts, Cytokines and Other Antigenic Molecules of Cynomolgus Monkeys (Macaca fascicularis) by Using Anti-Human Cross-Reactive Antibodies
- COMPARISON BETWEEN DENSITY GRADIENT CENTRIFUGAL METHOD AND WHOLE BLOOD METHOD FOR LYMPHOCYTE SURFACE MARKER ANALYSIS WITH FLOW-CYTOMETRY IN RHESUS MONKEYS
- Establishment of Two Substrains, Diabetes-Prone and Non-Diabetic, from Long-Evans Tokushima Lean (LETL) Rats
- MONITORING OF GENE EXPRESSION IN DIFFERENTIATION OF EMBRYOID BODIES FROM CYNOMOLGUS MONKEY EMBRYONIC STEM CELLS IN THE PRESENCE OF BISPHENOL A
- Essentials for starting a pediatric clinical study (3) : Dynamic changes in early development of immune system in macaque monkeys : The significance from standpoint of preclinical toxicity test using nonhuman primates
- Strategies for Tolerance Induction against Xenogeneic-Gene-Transduced Hematopoietic Stem Cells and Their Selective Expansion in a Monkey Model
- STANDARDIZATION OF DENSITY GRADIENT CENTRIFUGAL METHOD FOR LYMPHOCYTE SURFACE MARKER ANALYSIS WITH FLOW-CYTOMETRY IN CYNOMOLGUS MONKEYS.
- Behavioral evidence of color vision deficiency in a protanomalia chimpanzee (Pan troglodytes)
- Polymorphic variations in long- and middle-wavelength-sensitive opsin gene loci in crab-eating monkeys
- The Repeated Procedure of Weaning and Peer Group Formation Causes Accumulation of Stress and Changes of Plasma Cortisol Level and Natural Killer Activity in Squirrel Monkeys (Saimiri sciureus)
- Familial early onset macular degeneration in cynomolgus monkeys (Macaca fascicularis)
- Osteolytic and osteosclerotic lesion in the femur associated with pustulosis palmaris plantaris
- Locking of the thumb in a patient with de Quervain's disease : a case report
- Senile Plaques in an Aged Western Lowland Gorilla
- Expression of proinflammatory cytokines and its relationship with virus infection in the brain of macaques inoculated with macrophage-tropic simian immunodeficiency virus
- Simple Method for Assaying Serum Oxytocin and Changes of Serum Oxytocin Level during Parturition in Cynomolgus Monkeys
- Possible Role of Peripheral CD14^ Monocytes in the Development of Collagen-Induced Arthritis in Cynomolgus Monkeys (Macaca fascicularis)
- Non-human Primate Model in New Field of Immunology, Psychoneuro-Immunology : Significance for Assessment of Environment Enrichment and Psychological Well-being
- White matter activated glial cells produce BDNF in a stroke model of monkeys
- マウスノロウイルスS7株に対する特異抗体を検出するための間接ELISA法および間接蛍光抗体法