老齢マカクサルにおける加齢性学習能力の減衰と海馬歯状回のニューロン新生との相関関係
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概要
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Newborn neurons are continuously produced in the hippocampus, which may be involved in several cognitive functions, including learning and memory, throughout life. However, both hippocampus-dependent cognitive functions and the level of adult neurogenesis are gradually attenuated as aging progresses. Few studies have explored the relationship between adult neurogenesis and cognitive functions, especially in primates. In this study, we evaluated learning performance and hippocampal neurogenesis utilizing young and aged cynomolgus monkeys. Significant attenuations in learning performance and adult neurogenesis were detected in aged monkeys. Interestingly, there was a positive correlation between learning performance and the level of neurogenesis. Our findings suggest that cognitive functions and adult neurogenesis may have some interdependent relationships during aging.
- 社団法人 日本実験動物学会の論文
著者
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相澤 憲
Department of Integrated Biosciences, The University of Tokyo
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揚山 直英
Tsukuba Primate Research Center, National Institute of Biomedical Innovation
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横山 ちひろ
Functional Probe Research Laboratory, Molecular Imaging Research Program, RIKEN Kobe Institute
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HISATSUNE Tatsuhiro
Department of Integrated Biosciences, The University of Tokyo
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Hisatsune Tatsuhiro
Department Of Applied Biological Chemistry The University Of Tokyo
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Yokoyama Chihiro
Functional Probe Research Lab, Molecular Imaging Research Program, RIKEN Frontier Research System
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Ageyama Naohide
Tsukuba Primate Center, National Institute of Infectious Diseases
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Ageyama Naohide
Tsukuba Primate Center For Medical Science National Institute Of Infectious Diseases
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Yokoyama Chihiro
Functional Probe Research Lab Riken Frontier Research System
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AIZAWA Ken
Department of Integrated Biosciences, The University of Tokyo
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Ageyama Naohide
Tsukuba Primate Research Center, National Institute of Biomedical Innovation
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