Strong Influence of the Processing of the Antigen on Negative Effects on T Cell Activation by Regions Outside the Determinant Area of Bovine α_<s1>-Casein
スポンサーリンク
概要
- 論文の詳細を見る
α_<s1>-Casein can elicit a proliferative response in responding T cell clone 3D20 cells (specific for I-A^b plus fragment 136-151), even when using fixed splenic antigen-presenting cells (APC) not carrying antigen processing ability. The order of potency of each tested antigen for fixed APC was the determinant peptide (136-151)>the long peptide (136-195)>the intact protein (199 residues), indicating that regions outside the determinant area negatively affected the stimulatory potency of the antigens. On the other hand, the order for normal splenic APC was the short peptide>the intact protein>the long peptide. This shows that negative effects by regions outside the determinant area were strongly influenced by the antigen processing.
- 社団法人日本農芸化学会の論文
- 1992-10-23
著者
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HISATSUNE Tatsuhiro
Department of Integrated Biosciences, The University of Tokyo
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Hisatsune Tatsuhiro
Department Of Applied Biological Chemistry The University Of Tokyo
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Hisatsune T
Univ. Tokyo Tokyo Jpn
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ENOMOTO Atsushi
Department of Pathology, Nagoya University Graduate School of Medicine
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KAMINOGAWA Shuichi
Department of Food Science and Technology, College of Bioresource Sciences, Nihon University
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Nishijima Ken-ichi
Department of Biotechnology, Graduate School of Engineering, Nagoya University
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Nishijima Ken-ichi
Nagoya University
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Kaminogawa Shuichi
Department Of Applied Biological Chemistry Division Of Agriculture And Agricultural Life Sciences Th
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AMETANI Akio
Applied Biological Chemistry, University of Tokyo
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AMETANI Akio
Department of Applied Biological Chemistry, The University of Tokyo
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Kametani Y
Applied Biological Chemistry University Of Tokyo
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Ametani Akio
Department Of Applied Biological Chemistry The University Of Tokyo:(present Address)torrey Pines Ins
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Kaminogawa S
Dep. Of Food Sci. And Technol. Nihon Univ.
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Enomoto Atsushi
Department Of Biological And Chemical Engineering Faculty Of Engineering Gunma University
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Kaminogawa Shuichi
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Nishijima Ken-ichi
Department Of Biotechnology Graduate School Of Engineering Nagoya University
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Nishijima Ken-ichi
Department Of Applied Biological Chemistry The University Of Tokyo:(present Address)department Of Bl
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