Bacteroides Induce Higher IgA Production Than Lactobacillus by Increasing Activation-Induced Cytidine Deaminase Expression in B Cells in Murine Peyer’s Patches
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概要
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The gut mucosal immune system is crucial in host defense against infection by pathogenic microbacteria and viruses via the production of IgA. Previous studies have shown that intestinal commensal bacteria enhance mucosal IgA production. However, it is poorly understood how these bacteria induce IgA production and which genera of intestinal commensal bacteria induce IgA production effectively. In this study, we compared the immunomodulatory effects of Bacteroides and Lactobacillus on IgA production by Peyer’s patches lymphocytes. IgA production by Peyer’s patches lymphocytes co-cultured with Bacteroides was higher than with Lactobacillus. In addition, the expression of activation-induced cytidine deaminase increased in co-culture with Bacteroides but not with Lactobacillus. We found that intestinal commensal bacteria elicited IgA production. In particular, Bacteroides induced the differentiation of Peyer’s patches B cell into IgA+ B cells by increasing activation-induced cytidine deaminase expression.
著者
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ITOH Kikuji
Department of Veterinary Public Health, Graduate School of Agricultural and Life Sciences, Universit
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TAKAHASHI Yoshimasa
Department of Pharmacology, Gifu Pharmaceutical University
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TAKAHASHI Kyoko
Department of Food Science and Nutrition, School of Human Environmental Sciences, Mukogawa Women’s U
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KAMINOGAWA Shuichi
Department of Food Science and Technology, College of Bioresource Sciences, Nihon University
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HOSONO Akira
Department of Food Science and Technology College of Bioresource Sciences, Nihon University
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HIRAYAMA Kazuhiro
Department of Veterinary Public Health, Faculty of Agriculture, The University of Tokyo
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YANAGIBASHI Tsutomu
Department of Food Science and Technology, Nihon University
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OYAMA Akihito
Department of Food Science and Technology, Nihon University
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TSUDA Masato
Department of Food Science and Technology, Nihon University
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HACHIMURA Satoshi
Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University o
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Oyama Akihito
Department Of Food Science And Technology Nihon University
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