Screening for the Immunopotentiating Activity of Food Microorganisms and Enhancement of the Immune Response by Bifidobacterium adolescentis M101-4

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概要

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• The ability for such lymphocyte activation as growth of the spleen and Peyer's patch (PP) cells from unprimed BALB/c mice, and of lymph node (LN) cells from mice immunized with hen's egg ovomucoid (OM) was assayed by using sonicated microorganisms. The occurrence of immunopotentiating activity was strikingly dependent on the properties of individual strains, rather than on the species or microbial culture conditions. All the tested Bifidobacterium strains, especially B. adolescentis M101-4, showed strong mitogenic activity in those assays, and also enhanced the production of the anti-OM antibody by LN cells, while they did not induce the growth of thymocytes. Similar results were obtained from experiments using germ-free (GF) mice. These results suggest that the activation with B. adolescentis M101-4 was not due to any secondary stimulation of lymphocytes primed with bacteria in the gut or environment, but to direct or indirect activity toward B cells that was intrinsic to the strain.

• 社団法人日本農芸化学会の論文
• 1993-12-23

著者

• ENOMOTO Atsushi

  Department of Pathology, Nagoya University Graduate School of Medicine

• Mori Hiroaki

  Department Of Agricultural Chemistry The University Of Tokyo

• SATO Yumi

  Department of Chemistry, Faculty of Science, Kyushu University

• Sato Y

  Nippon Steel Corp. Kawasaki Jpn

• KAMINOGAWA Shuichi

  Department of Food Science and Technology, College of Bioresource Sciences, Nihon University

• MOTOSHIMA Hidemasa

  Research Center, Yotsuba Milk Products Co., Ltd.

• Kaminogawa Shuichi

  Department Of Applied Biological Chemistry Division Of Agriculture And Agricultural Life Sciences Th

• Ike Fumio

  The Institute Of Physical And Chemical Research (riken)

• AMETANI Akio

  Applied Biological Chemistry, University of Tokyo

• AMETANI Akio

  Department of Applied Biological Chemistry, The University of Tokyo

• Kametani Y

  Applied Biological Chemistry University Of Tokyo

• Ametani Akio

  Department Of Applied Biological Chemistry The University Of Tokyo:(present Address)torrey Pines Ins

• LEE Jonghwa

  Department of Applied Biological Chemistry, The University of Tokyo

• Lee Jonghwa

  Department Of Applied Biological Chemistry The University Of Tokyo:(present Address)department Of Fo

• Kaminogawa S

  Dep. Of Food Sci. And Technol. Nihon Univ.

• Enomoto Atsushi

  Department Of Biological And Chemical Engineering Faculty Of Engineering Gunma University

• Motoshima H

  Research And Development Department Yotsuba Milk Products Co.

• Motoshima Hidemasa

  Research Center Yotsuba Milk Products Co. Ltd.

• Kaminogawa Shuichi

  Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo

• Lee Jonghwa

  Department Of Applied Biological Chemistry The University Of Tokyo

• Sato Yumi

  Department Of Chemistry Faculty Of Science Kyushu University

• Motoshima Hidemasa

  Research and Development Department, Yotsuba Milk Products Co.

• Sato Yumi

  Department of Agricultural Chemistry, The University of Tokyo

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