Suppression of Collagen-Induced Arthritis in DBA/1J Mice by Preimmunization with House Dust Mite Extract

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概要

• 論文の詳細を見る

• Collagen-induced arthritis (CIA) can be induced in DBA/1J mice by immunization with bovine type II collagen (bCII) and is a model of some types of human autoimmune rheumatoid arthritis. In this study we examined whether preimmunization of the mice with various antigens could inhibit the development of CIA. Preimmunization of the mice with an extract of the house dust mite Dermatophagoides farinae (mite antigen), chicken ovalbumin, or keyhole limpet hemocyanin strongly inhibited CIA development, but hen egg lysozyme, β-lactoglobulin from bovine milk or myelin basic protein from guinea pig brain did not substantially affect CIA development. Splenic T cells and serum antibodies specific for mite antigen did not cross-react with bCII. Preimmunization of the mice with mite antigen did not affect the IFN-γ and proliferative response of splenic T cells to bCII, nor serum antibody responses. The most inhibitory constituent had a molecular weight between 1,000 and 10,000.

• 社団法人日本農芸化学会の論文
• 2001-05-23

著者

• Matsumoto Takashi

  Department of Gynecologic Oncology, Shikoku Cancer Center

• Matsumoto Takashi

  Department Of Cardiology Kyoto First Red Cross Hospital

• KAMINOGAWA Shuichi

  Department of Food Science and Technology, College of Bioresource Sciences, Nihon University

• HONDA Aki

  Department of Applied Chemistry, Faculty of Science and Technology, Keio University

• Kaminogawa Shuichi

  Department Of Applied Biological Chemistry Division Of Agriculture And Agricultural Life Sciences Th

• Matsumoto T

  Applied Biological Chemistry University Of Tokyo

• HONDA Aki

  Applied Biological Chemistry, University of Tokyo

• AMETANI Akio

  Applied Biological Chemistry, University of Tokyo

• AMETANI Akio

  Department of Applied Biological Chemistry, The University of Tokyo

• Kametani Y

  Applied Biological Chemistry University Of Tokyo

• Ametani Akio

  Department Of Applied Biological Chemistry The University Of Tokyo:(present Address)torrey Pines Ins

• Honda Akira

  Applied Biological Chemistry University Of Tokyo

• Honda Aki

  Department Of Anesthesiology Kitasato University School Of Medicine

• Kaminogawa S

  Dep. Of Food Sci. And Technol. Nihon Univ.

• Kaminogawa Shuichi

  Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo

• Matsumoto Takashi

  Rice Genome Research Program National Institute Of Agrobiological Sciences

• Matsumoto Takashi

  Department Of Applied Physics Waseda University

• Matsumoto Takashi

  Department of Applied Material Science, Faculty of Integrated Arts and Sciences, University of Tokushima

• Matsumoto Takashi

  Department of Applied Material Science, Faculty of Integrated Arts and Science, University of Tokushima

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