Poly I:C induces a reduction of voluntary physical activity, but it is not involved with interferon-beta pathway in mice
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概要
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One characteristic sickness behavior is demonstrated by a reduction in voluntary wheel-running activity during infection. Among synthetic double-stranded (ds) RNA, polyriboinosinic: polyribocytidylic acid (poly I:C) activates to produce interferon (IFN)-β, which plays an important role in anti-viral activity and host-defense. However, what is unknown is how to regulate voluntary wheel-running activity during poly I:C infection. To determine whether poly I:C-induced IFN-β production is responsible for reduced spontaneous physical activity, we measured poly I:C-induced changes in voluntary wheel-running activity in mice. In this experiment, the mice were injected with poly I:C (0-5mg/kg i.v.) and/or anti-IFN-β neutralizing antibody (1.5×10^5U/kg i.v.). In addition, we observed the direct effect of recombinant IFN-β (rIFN-β: 5.0× 10^4 and 2.5×10^5U/kg i.v.) injection on wheel-running behavior. Poly I: C treatment dose-dependently reduced wheel-running activity, and poly I:C treatment induced an increase in plasma IFN-β in mice. However the activity was not attenuated by the neutralizing antibody specific to IFN-β treatment. Additionally, the wheel-running activity in rIFN-β treated mice was maintained, although the rIFN-β treated mice shown a high IFN-γ inducible protein (IP)-10 concentration in plasma compared with the vehicle group. Our results suggest that the transient reduction in physical activity after poly I:C injection is induced dose dependently, but the mediator might not be poly I:C-induced IFN-β.
- 日本体力医学会の論文
- 2008-02-01
著者
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Matsumoto Takashi
Department of Gynecologic Oncology, Shikoku Cancer Center
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Shiva Daisuke
Division of Health Science, Kawasaki University of Medical Welfare
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Kawanishi Noriaki
Department of Health and Sports Science, Kawasaki University of Medical Welfare
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Yano Hiromi
Kawasaki University Of Medical Welfare
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Matsumoto Takashi
Department Of Cardiology Kyoto First Red Cross Hospital
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YANO Hiromi
Department of Health and Sports Science, Kawasaki University of Medical Welfare
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Yano Hiromi
Department Of Health & Sports Science Kawasaki University Of Medical Welfare
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Shiva Daisuke
Kawasaki University Of Medical Welfare
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Kawanishi Noriaki
Kawasaki University of Medical Welfare
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Shiva Daisuke
Division Of Health Science Kawasaki University Of Medical Welfare
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Yano Hiromi
Department Of Cardiovascular Surgery Hachioji Medical Center Of Tokyo Medical University
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Matsumoto Takashi
Microbiology Department Of Infectious Disease Faculty Of Medicine Oita University
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Matsumoto Takashi
Department Of Applied Physics Waseda University
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Matsumoto Takashi
Department of Applied Material Science, Faculty of Integrated Arts and Sciences, University of Tokushima
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Matsumoto Takashi
Department of Applied Material Science, Faculty of Integrated Arts and Science, University of Tokushima
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