In Vivo Macrophage-stimulation Activity of the Enzyme-degraded Water-soluble Polysaccharide Fraction from a Marine Alga (Gracilaria verrucosa)
スポンサーリンク
概要
- 論文の詳細を見る
The water-soluble polysaccharide fraction from Gracilaria verrucosa (GWS) has been reported to increase the phagocytic activity of mice [Yoshizawa et al., Nippon Shokuhin Kogyo Gakkaishi, 41, 557-560 (1994)]. In this study, the macrophage-stimulation activity of enzyme-degraded GWS (GWS-E) was investigated by intraperitoneally and orally administering GWS-E to mice. The intraperitoneal administration of GWS-E increased the number of peritoneal exudate cells (PEC), and increased the phagocytic activity and oxygen radical-secreting activity (spontaneous chemiluminescence) of PEC. This administration could also stimulate splenic macrophages (SPM), increasing radical-secreting activity. When GWS-E was administered orally, the radical-secreting activity of PEC and SPM increased. In this case of oral administration, the activity of SPM increased in a dose-dependent manner, while that of PEC had an optimum dose. These results indicate that GWS-E had macrophage-stimulation activity in vivo and would be suitable as a source for a physiologically functional food with protective and immunopotentiating activity.
- 社団法人日本農芸化学会の論文
- 1996-10-23
著者
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KAMINOGAWA Shuichi
Department of Food Science and Technology, College of Bioresource Sciences, Nihon University
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FUKUI Fumio
Research and Development Center, Showa Sangyo Co., Ltd.
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Fukui F
Showa Sangyo Co. Ltd. Ibaraki Jpn
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Fukui Fumio
Research And Development Center Showa Sangyo Co. Ltd.
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Fukui Fumio
Fermentation Research Laboratories Sankyo Co. Ltd.
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Kaminogawa Shuichi
Department Of Applied Biological Chemistry Division Of Agriculture And Agricultural Life Sciences Th
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YOSHIZAWA Yasuko
Research and Development Center, Showa Sangyo Co., Ltd.
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AMETANI Akio
Applied Biological Chemistry, University of Tokyo
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AMETANI Akio
Department of Applied Biological Chemistry, The University of Tokyo
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Kametani Y
Applied Biological Chemistry University Of Tokyo
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Ametani Akio
Department Of Applied Biological Chemistry The University Of Tokyo:(present Address)torrey Pines Ins
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Yoshizawa Y
Research And Development Center Showa Sangyo Co. Ltd.
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Itoh M
T. Hasegawa Co. Ltd. Kawasaki Jpn
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Nomura K
Shin Nihon Chemical Co. Ltd.
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TSUNEHIRO Jun
Research and Development Center, Showa Sangyo Co., Ltd.,
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NOMURA Kazuyo
R&D Department, Shin Nihon Chemical Co., Ltd.
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ITOH Masao
R&D Department, Shin Nihon Chemical Co., Ltd.
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Tsunehiro J
Showa Sangyo Co. Ltd. Ibaraki Jpn
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Tsunehiro Jun
Research And Development Center Kashima Laboratory Showa Sangyo Co. Ltd.
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Kaminogawa S
Dep. Of Food Sci. And Technol. Nihon Univ.
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Kaminogawa Shuichi
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Yoshizawa Yasuko
Research & Development Center Showa Sangyo Co. Ltd
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