Cytokine Responses of Intestinal Epithelial-Like Caco-2 Cells to Non-Pathogenic and Opportunistic Pathogenic Yeasts in the Presence of Butyric Acid
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概要
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Candida albicans, Saccharomyces cerevisiae and their cell wall components, zymosan and glucan, have been shown to stimulate interleukin-8 (IL-8/CXCL-8) production by intestinal epithelial cell-like Caco-2 cells pre-cultured with 10 mM butyric acid. We examined in this study whether these yeasts also altered the production of other cytokines and cyclooxygenases (COXs) by Caco-2 cells. Culturing Caco-2 cells with 10 mM butyric acid and 15% FBS for 4 days enhanced the basal levels of mRNA encoding IL-6, IL-8, IL-18, monocyte chemoattractant protein (MCP)-1, stem cell factor, transforming growth factor (TGF)-β1, TGF-β3, tumor necrosis factor (TNF)-α, COX-1, and COX-2, but not of granulocyte-macrophage colony-stimulating factor (GM-CSF) and TGF-β2. The inclusion of live S. cerevisiae or C. albicans further enhanced the production of IL-8, but not of the other cytokines and COXs. The non-pathogenic yeasts, C. kefyr, C. utilis, C. versatilis, Kluyveromyces lactis, K. marxianus, Schizosaccharomyces pombe and Zygosaccharomyces rouxii, used for the production of fermented foods and probiotics, and the opportunistic pathogens, C. glabrata, C. krusei, C. parapsilosis and C. tropicalis, isolated from human tissue samples also enhanced IL-8 secretion by Caco-2 cells.
- 社団法人 日本農芸化学会の論文
- 2007-10-23
著者
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KAMINOGAWA Shuichi
Department of Food Science and Technology, College of Bioresource Sciences, Nihon University
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TOTSUKA Mamoru
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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Hosoi Tomohiro
Department Of Applied Biological Chemistry The University Of Tokyo:(present Address)tokyo Metropolit
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Totsuka Mamoru
Dep. Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Univ. Of
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Totsuka M
Department Of Applied Biological Chemistry The University Of Tokyo
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Totsuka Mamoru
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Hosoi Tomohiro
Tokyo Metropolitan Food Technol. Res. Center
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Kaminogawa Shuichi
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Saegusa Shizue
Tokyo Metropolitan Food Technology Research Center
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Kaminogawa Shuichi
Dep. Of Applied Biological Chemistry The Univ. Of Tokyo
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