Saccharomyces cerevisiae and Candida albicans Stimulate Cytokine Secretion from Human Neutrophil-Like HL-60 Cells Differentiated with Retinoic Acid or Dimethylsulfoxide
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概要
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We investigated whether non-pathogenic Saccharomyces cerevisiae and human commensal opportunistic pathogenic Candida albicans stimulate cytokine responses of human neutrophil-like HL-60 cells pre-treated with either 1 μM retinoic acid or 1.25% dimethyl sulfoxide (DMSO). Intact and heat-killed S. cerevisiae enhanced secretion of interleukin (IL)-1β, IL-6, IL-8, IL-12, IL-18, MCP-1/CCL2 and TNF-α from retinoic acid-treated HL-60 cells, accompanied by alterations in mRNA expression of the cytokines. Heat-killed C. albicans promoted secretion of IL-6, IL-8, IL-12, MCP-1 and TNF-α, while intact C. albicans slightly enhanced secretion of IL-1β, IL-8 and IL-18. In response to yeast stimuli, retinoic acid-treated HL-60 cells generally secreted cytokines more strongly than DMSO-treated HL-60 cells. Gene expression levels of Toll-like receptor (TLR)1, TLR2, TLR4, TLR6 and dectin-1 in HL-60 cells were additionally affected by retinoic acid or DMSO and by co-culturing with S. cerevisiae or C. albicans. Our results suggest that both intact and heat-killed S. cerevisiae and C. albicans induce cytokine responses of neutrophils in the intestine, and stimulate host immune function.
- 社団法人 日本農芸化学会の論文
- 2009-12-23
著者
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KAMINOGAWA Shuichi
Department of Food Science and Technology, College of Bioresource Sciences, Nihon University
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TOTSUKA Mamoru
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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Hosoi Tomohiro
Department Of Applied Biological Chemistry The University Of Tokyo:(present Address)tokyo Metropolit
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Totsuka Mamoru
Dep. Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Univ. Of
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Totsuka M
Department Of Applied Biological Chemistry The University Of Tokyo
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Totsuka Mamoru
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Hosoi Tomohiro
Tokyo Metropolitan Food Technol. Res. Center
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Kaminogawa Shuichi
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Saegusa Shizue
Tokyo Metropolitan Food Technology Research Center
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Kaminogawa Shuichi
Dep. Of Applied Biological Chemistry The Univ. Of Tokyo
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