Antigen Feeding Increases Frequency and Antigen-specific Proliferation Ability of Intraepithelial CD4^+ T Cells in αβ T Cell Receptor Transgenic Mice(Food & Nutrition Science)
スポンサーリンク
概要
- 論文の詳細を見る
To study how intestinal intraepithelial lymphocytes (IEL) are affected by orally ingested antigen, the phenotypes and responses of the IEL in mice expressing a transgenic T cell receptor αβ (TCR αβ) specific for ovalbumin (OVA) were analyzed after feeding OVA. In the OVA-fed mice, the abundance of αβ-IEL as a proportion of the total IEL population increased and the frequency of CD4^+ cells increased within the TCR αβ^+ IEL population. CD4^+ IEL from OVA-fed transgenic mice proliferated in vitro more markedly in response to antigen stimulation than IEL from mice fed the control diet. These results indicate that antigen-specific proliferation of CD4^+ IEL was amplified as a result of oral administration of antigen.
- 社団法人日本農芸化学会の論文
- 2003-06-23
著者
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Ishikawa H
Department Of Internal Medicine School Of Medicine Keio University
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Goto Machio
Hitachi Instrument Engineering Co. Ltd.
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Ishii Hiromasa
慶応義塾大学 内
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Ishii Hiromasa
北里研究所メディカルセンター病院
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SATO Takahide
Graduate School of Science and Technology, Chiba University
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Sato T
Fac. Horti. Chiba Univ.
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Sato Takahide
Graduate School Of Science And Technology Chiba University
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Goto M
Mie Univ. Tsu Jpn
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Ishikawa H
Department Of Microbiology Keio University School Of Medicine
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ISHIKAWA Hiromichi
Department of Microbiology, Keio University, School of Medicine
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HABU Sonoko
Division of Host Defense Mechanism, Department of Immunology, Tokai University School of Medicine
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KAMINOGAWA Shuichi
Department of Food Science and Technology, College of Bioresource Sciences, Nihon University
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HACHIMURA Satoshi
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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Kumagai Yoshihiro
Department Of Microbiology And Immunology Nippon Medical School
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Ishikawa Hiromichi
Central Research Laboratories Hokko Chemical Industry Co. Lid.
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Kaminogawa Shuichi
Department Of Applied Biological Chemistry Division Of Agriculture And Agricultural Life Sciences Th
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Ishii Hiroyuki
Division Of Gastroenterology & Hepatology Department Of Internal Medicine School Of Medicine Kei
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Ishii H
Department Of Internal Medicine School Of Medicine Keio University
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Ishii Hiromasa
慶応義塾大学 医学部内科学
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AMETANI Akio
Applied Biological Chemistry, University of Tokyo
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AMETANI Akio
Department of Applied Biological Chemistry, The University of Tokyo
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Kametani Y
Applied Biological Chemistry University Of Tokyo
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Ametani Akio
Department Of Applied Biological Chemistry The University Of Tokyo:(present Address)torrey Pines Ins
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Habu S
Division Of Host Defense Mechanism Department Of Immunology Tokai University School Of Medicine
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Habu Sonoko
Division Of Host Defense Mechanism Department Of Immunology Tokai University School Of Medicine
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Sato Takenhito
Department Of Immunology Tokai University School Of Medicine
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TOTSUKA Mamoru
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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GOTO Masao
Department of Applied Biological Chemistry, The University of Tokyo
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SATO Takehito
Division of Host Defense Mechanisms, Department of Immunology, Tokai University School of Medicine
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Kaminogawa S
Dep. Of Food Sci. And Technol. Nihon Univ.
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Totsuka Mamoru
Dep. Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Univ. Of
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Totsuka M
Department Of Applied Biological Chemistry The University Of Tokyo
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Totsuka Mamoru
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Ishikawa Hiromichi
Department Of Internal Medicine School Of Medicine Keio University
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Hachimura S
Res. Center For Food Safety Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Kaminogawa Shuichi
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Hachimura Satoshi
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Ishikawa Hiroshi
Society Of Highly Advanced Medical Technology
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Sato Tsutomu
Department Of Applied Biological Chemistry Faculty Of Agriculture And Graduate School Of Science And
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Hachimura Satoshi
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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