A REPEATED-DOSE DERMAL TOXICITY STUDY OF HYDROPHOBICALLY MODIFIED HYDROXYPROPYL METHYLCELLULOSE IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
A six-month repeated-dose dermal toxicity study followed by a 30-day recovery test of hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC), a new cellulose derivative used as a thickener for topical pharmaceuticals, was conducted using rats. Aqueous paste of HM-HPMC was applied to the skin of rats once daily at dose levels up to 60 mg/kg/day, which was the highest dose that could be administered. Items checked included general signs, urinalysis, hematology, ophthalmology, and histopathology. One rat died during the administration period owing to a malignant tumor in the hemopoietic system, which was not attributed to the test substance. Statistically significant differences were found in some test results, but those were not dose-dependent and were considered to be incidental or spontaneous. It was concluded that the test substance was not toxic upon chronic dermal administration at dose levels up to 60 mg/kg/day.
- 日本トキシコロジー学会の論文
- 1997-08-10
著者
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田中 修
甲南大・理工・生物
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Ishikawa H
Department Of Internal Medicine School Of Medicine Keio University
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Ishii Hiromasa
慶応義塾大学 医学部内科学教室
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Tanaka O
Institute Of Pharmaceutical Sciences Faculty Of Medicine Hiroshima University
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鎌田 喜一郎
長岡技術科学大学化学系
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Ishikawa H
Department Of Microbiology Keio University School Of Medicine
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Tanaka O
Department Of Biology Faculty Of Science And Engineering Konan University
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Tanaka O
Shimane Medical University
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Ishii Hiroyuki
Division Of Gastroenterology & Hepatology Department Of Internal Medicine School Of Medicine Kei
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Obara S
Shin‐etsu Chemical Co. Ltd. Niigata Jpn
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Obara Sakae
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
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Otsuka Michio
Bio-medical Research Laboratories Co. Ltd.
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ICHIKAWA Naoto
Bio-Medical Research Laboratories Co., Ltd.
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TANAKA Osamu
Bio-Medical Research Laboratories Co., Ltd.
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KAWANABE Mikiko
Bio-Medical Research Laboratories Co., Ltd.
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NIIKURA Yoshiyuki
Bio-Medical Research Laboratories Co., Ltd.
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MUTO Hiroaki
Specialty Chemicals Research Center, Shin-Etsu Chemical Co., Ltd.
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ISHII Hiroyuki
Bio-Medical Research Laboratories Co., Ltd.
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KOMATSU Masahiko
Bio-Medical Research Laboratories Co., Ltd.
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Ichikawa Naoto
Bio-medical Research Laboratories Co. Ltd.
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Muto H
Shin‐etsu Chemical Co. Ltd. Niigata Jpn
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Muto Hiroaki
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
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Tanaka O
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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Niikura Yoshiyuki
Bio-medical Research Laboratories Co. Ltd.
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Kawanabe Mikiko
Bio-medical Research Laboratories Co. Ltd.
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