Induction therapy with twice-daily interferon-beta does not improve the therapeutic efficacy of consensus interferon monotherapy for chronic hepatitis C
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概要
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We examined therapeutic superiority of induction therapy with twice-daily IFN-β (3X2=6 million units/day) onto 6-months consensus interferon monotherapy for chronic hepatitis C. Patients were randomly assigned to monotherapy without (group I, n=16) and with induction therapy (group II, n=12). The mean age of group II was older than that of group I, and other baseline condition was not statistically significant. Sustained virological response (SVR) rates of group I and II were 81.3% (13/16) and 58.3% (7/12), respectively (p=0.365). SVR rates in patients with genotype 1b were 66.7% (4/6) and 0% (0/2, because of drop-out), and those with high viral load were 70% (7/10) and 75% (6/8) in group I and II, respectively (p=1.000). Drop-out rates during therapy were 6.3% (1/16) and 33.3% (4/12) in group I and II, respectively (p=0.176). Age less than 50 years was the only independent factor that was shown by multivariate logistic model analysis to be associated with a sustained virological response. Although randomization failed to produce and equal age distribution in the two groups in this study, our results suggest that induction therapy with twice-daily IFN-β has no beneficial effect on the efficacy of monotherapy with consensus interferon, probably because of the higher drop-out rates and incidence of adverse reactions with induction therapy.
- 2006-09-01
著者
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Ishikawa H
Department Of Internal Medicine School Of Medicine Keio University
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Ishii Hiromasa
Department of Public Health, Tokai University School of Medicine
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Suzuki Hiramitsu
群馬大学 衛生学
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Ishii Hiromasa
慶応義塾大学 医学部内科学教室
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Ishii Hiromasa
北里研究所メディカルセンター病院
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TADA Shinichiro
Department of Internal Medicine, School of Medicine, Keio University
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SAITO Hidetsugu
Department of Internal Medicine, School of Medicine, Keio University
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HIBI Toshifumi
Department of Internal Medicine, School of Medicine, Keio University
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Horie Y
Division Of Gastroenterology And Hepatology Department Of Internal Medicine School Of Medicine Keio
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Ishikawa H
Department Of Microbiology Keio University School Of Medicine
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Ishii Hiromasa
Department Of Gastroenterology Keio University School Of Medicine
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Hibi Toshifumi
Keio Cancer Center School Of Medicine Keio University
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EBINUMA Hirotoshi
Department of Internal Medicine, School of Medicine, Keio University
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KUMAGAI Naoki
Kitasato Institute Hospital
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INAGAKI Yasutaka
Nihon Kohkan Hospital
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NISHIDA Jiro
Tokyo Dental Collage Ichikawa General Hospital
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EINUMA Hirotoshi
Department of Internal Medicine, School of Medicine, Keio University
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Saito Hidetsugu
慶応義塾大学 医学部内科学
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Saito H
Department Of Internal Medicine School Of Medicine Keio University
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Saito Hidetsugu
Department Of Internal Medicine School Of Medicine Keio University
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Saito Hidetsugu
Department Of Internal Medicine Division Of Gastroenterology Keio University School Of Medicine
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KASHIWAZAKI Kazuo
Tachikawa Hospital
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YOSHIDA Takeshi
Saitama Social Insurance Hospital
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ZEKI Shigeyuki
Keiyu Hospital
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YOSHIDA Hideo
Eiju General Hospital
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YOSHIOKA Masahiro
Minami-Tama Hospital
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Hibi T
Keio Univ. Tokyo Jpn
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SUZUKI Hidekazu
Department of Internal Medicine, School of Medicine, Keio University
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Ishikawa Hiromichi
Central Research Laboratories Hokko Chemical Industry Co. Lid.
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Ishii Hiroyuki
Division Of Gastroenterology & Hepatology Department Of Internal Medicine School Of Medicine Kei
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Ishii H
Department Of Internal Medicine School Of Medicine Keio University
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Ishii Hiromasa
慶応義塾大学 医学部内科学
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Hibi Toshifumi
Department Of Digestive Organ Medicine Keio University School Of Medicine
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Suzuki H
Department Of Internal Medicine School Of Medicine Keio University
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Mizuno Yoshio
Minami-tama Hospital
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Shiozu Hidetoshi
Division Of Gastroenterology And Hepatology Department Of Internal Medicine Keio University School O
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Suzuki H
Kyoto Univ. Kyoto
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KUMAGAI Naoki
the Department of Internal Medicine
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Einuma Hirotoshi
Division Of Gastroenterology And Hepatology Department Of Internal Medicine School Of Medicine Keio
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Ebinuma Hirotoshi
Department Of Internal Medicine School Of Medicine Keio University
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Ishikawa Hiroshi
Society Of Highly Advanced Medical Technology
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Ebinuma Hirotoshi
Division Of Gastroenterology And Hepatology Department Of Internal Medicine School Of Medicine Keio
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Hibi Toshifumi
Division Of Gastroenterology And Hepatology Department Of Internal Medicine Keio University School O
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Ebinuma Hirotoshi
Division Of Gastroenterology And Hepatology Department Of Internal Medicine School Of Medicine Keio
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Hibi Toshifumi
Division Of Gastroenterology And Hepatology Department Of Internal Medicine Keio University School O
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Hibi Toshifumi
Division Of Gastroenterology And Hepatology Department Of Internal Medicine Keio University School O
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Tada Shinichiro
Department Of Internal Medicine School Of Medicine Keio University
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EBINUMA Hirotoshi
Department of Gastroenterology and Hepatology, Keio University School of Medicine
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