An Inverse Association between Serum Gamma Glutamyl Transpeptidase Activity and Breslow's Lifestyle Index; Its Practical Application for Screening of Subjects with Unhealthy Lifestyles
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概要
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We examined whether serum γGTP activity (γGTP) is associated with Breslow's lifestyle index and whether it could be used as a tool to detect subjects with unhealthy lifestyles. To that effect, 724 male Japanese workers excluding patients suffering from hepatitis virus infection, autoimmune liver diseases and apparently active bile duct diseases were cross-sectionally examined. γGTP was inversely associated with the total score of Breslow's index for all subjects (λ=30.643) and in subjects aged 40 or more (λ=37.073). The association was consistent even after adjustments of subjects' ages and levels of triglycerides, total cholesterol and uric acid (p=0.0001). Among the seven lifestyle factors comprising Breslow's index, improper habits of drinking (p<0.0001), smoking (p=0.0204), exercise (p=0.0189) and body weight control (p<0.0001 ), were associated with increased γGTP. Even in a survey in which subjects who had proper habits of drinking and body weight control were selectively examined, improper habits of smoking and exercise still tended to be associated with increased γGTP. Receiver operating characteristic curves indicated that γGTP was beneficial for detecting subjects who scored two or less on Breslow's index, at least in subjects aged 40 or more. γGTP was associated with insulin resistance level estimated by the homeostasis model assessment (p<0.0001), which was inversely associated with Breslow's index (p=0.0040). γGTP could be used as an objective substitute of Breslow's index, allowing us to identify subjects with low scores on Breslow's index, at least after sorting subjects properly. Such screening would enable interventions to correct subjects' unhealthy lifestyles, helping to solve lifestyle-related disease issues.
- 社団法人日本産業衛生学会の論文
著者
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Saito Ikuo
Health Center School Of Medicine Keio University
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HIBI Toshifumi
Department of Internal Medicine, School of Medicine, Keio University
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Hirose Hiroshi
Health Center School Of Medicine Keio University
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Saito Ikuo
Health Center Keio University
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YOKOYAMA Hirokazu
Health Center, Keio University
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OHGO Hideki
Department of Gastroenterology, School of Medicine, Keio University
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MORIYA Susumu
Department of Gastroenterology, School of Medicine, Keio University
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Saito Ikuo
The Health Center Keio University
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Hibi Toshifumi
Department Of Gastroenterology School Of Medicine Keio University
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Hibi Toshifumi
Department Of Digestive Organ Medicine Keio University School Of Medicine
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Saito Ikuo
Department Of Internal Medicine Keio University School Of Medicine
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Ohgo Hideki
Department Of Gastroenterology School Of Medicine Keio University
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Moriya Susumu
Department Of Gastroenterology School Of Medicine Keio University
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Yokoyama Hirokazu
Health Center Keio University
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Hirose Hiroshi
Health Center Keio University
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Saito IKuo
Health Center, School of Medicine, Keio University
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