Autoimmune Hepatitis Associated with Pulmonary Arterial Hypertension
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概要
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A 46-year-old woman presented with arthralgia. She had a history of fluctuating liver function impairment for 6 months. Laboratory investigations revealed elevated liver function test results, positive antinuclear antibodies and elevated serum IgG. The histological findings of a liver biopsy were interface hepatitis accompanied by plasmocytic infiltration with bridging fibrosis. There was no evidence of cirrhosis on pathological examination and no portal hypertension on endoscopic and radiographic studies. Autoimmune hepatitis was diagnosed, and treatment with prednisolone improved the liver dysfunction. After 6 months, she complained of dyspnea. Doppler echocardiography showed a dilated right ventricle, severe tricuspid insufficiency, and systolic pulmonary arterial pressure indicative of pulmonary arterial hypertension. We report this rare case of autoimmune hepatitis with pulmonary arterial hypertension.
著者
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Ohbu Makoto
Department Of Clinical Cytology School Of Allied Health Sciences Kitasato University:department Of P
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Tahara Kumiko
Department Of Internal Medicine Kitasato University
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Kondo Hirobumi
Department Of Internal Medicine Kitasato Institute Medical Center Hospital
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HOSHI Kenta
Department of Chemistry & Bioengineering, Iwate University
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Takeuchi Hajime
Department Of Biology Tokyo Metropolitan University
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Yokomori Hiroaki
Department Of Internal Medicine Kitasato Institute Medical Center Hospital
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Hibi Toshifumi
Department Of Digestive Organ Medicine Keio University School Of Medicine
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SATO Tooru
Department of Anatomy, School of Dentistry at Tokyo, Nippon Dental University
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Yoshida Hide
Department Of Internal Medicine Kitasato University Kitasato Institute Medical Center Hospital
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Kaneko Fumihiko
Department Of Internal Medicine Kitasato Institute Medical Center Hospital Kitasato University
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Sato Tooru
Department of Internal Medicine, School of Keio University
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Takeshita Tomochika
Departments of Internal Medicine, Kitasato Institute Medical Center Hospital, Kitasato University
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Yokomori Hiroaki
Departments of Internal Medicine, Kitasato Institute Medical Center Hospital, Kitasato University
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Takeuchi Hajime
Departments of Internal Medicine, Kitasato Institute Medical Center Hospital, Kitasato University
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Hoshi Kenta
Departments of Internal Medicine, Kitasato Institute Medical Center Hospital, Kitasato University
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Tahara Kumiko
Departments of Internal Medicine, Kitasato Institute Medical Center Hospital, Kitasato University
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