A Case of Drug-induced Hepatic Injury Associated with Sitagliptin
スポンサーリンク
概要
- 論文の詳細を見る
A 58-year-old man with a 10-year history of type II diabetes mellitus presented with progressive jaundice that began three days before admission. Thorough history-taking revealed that the patient had started on a new medication, sitagliptin, one month previously for the treatment of diabetes mellitus. Laboratory investigations showed severe liver dysfunction. Ultrasonography detected no extrahepatic biliary duct dilatation or gallstones. Abdominal computed tomography excluded pancreatic and hepatic focal lesions. Liver function improved upon discontinuation of sitagliptin. Drugs are an important, often unrecognized, cause of acute liver injury. This report presents a rare case in which sitagliptin was responsible for acute hepatic damage. As demonstrated, a thorough drug history is helpful in any case of unexplained liver injury.
著者
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Oda Masaya
Organized Center Of Clinical Medicine International University Of Health And Welfare
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Ohbu Makoto
Department Of Clinical Cytology School Of Allied Health Sciences Kitasato University:department Of P
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Tahara Kumiko
Department Of Internal Medicine Kitasato University
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Hibi Toshifumi
Division Of Gastroenterology And Hepatology Department Of Internal Medicine Keio University School O
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Takeuchi Hajime
Department Of Biology Tokyo Metropolitan University
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Yokomori Hiroaki
Department Of Internal Medicine Kitasato Institute Medical Center Hospital
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SHIMIZU Yuki
Department of Electronics and Electrical Engineering, Keio University
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Motoori Tadashi
Division Of Pathology Kitasato University Kitasato Medical Center Hospital
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Kaneko Fumihiko
Department Of Internal Medicine Kitasato Institute Medical Center Hospital Kitasato University
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Ohbu Makoto
Department of Pathology, School of Allied Health Sciences, Kitasato University, Japan
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Toyoda-Akui Megumi
Department of Internal Medicine, Kitasato Medical Center Hospital, Kitasato University, Japan
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Takeuchi Hajime
Department of Internal Medicine, Kitasato Medical Center Hospital, Kitasato University, Japan
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Oda Masaya
Organized Center of Clinical Medicine, International University of Health and Welfare, Japan
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Shimizu Yuki
Department of Internal Medicine, Kitasato Medical Center Hospital, Kitasato University, Japan
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Tahara Kumiko
Department of Internal Medicine, Kitasato Medical Center Hospital, Kitasato University, Japan
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