Dietary Nucleotides Increase the Proportion of a TCRγδ^+ Subset of Intraepithelial Lymphocytes (IEL) AND IL-7 Production by Intestinal Epithelial Cells (IEC) : Implications for Modification of Cellular and Molecular Cross-talk between IEL and IEC by Dieta

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We have investigated the effects of dietary nucleotides on intraepithelial lymphocytes (IEL) and intestinal epithelial cells (IEC) in weanling mice. The proportion of T-cell receptor (TCR) γδ^+ IEL in BALA/ c mice fed a diet supplemented with nucleotides (NT(+) diet) was significantly higher than that in mice fed the nucleotide-free diet, while the proportion of TCRαβ^+ IEL in NT(+) diet-fed mice was significantly decreased. The change of the TCRαβ^+/TCRγδ^+ ratio was mainly observed in a CD8αα^+ subset of IEL. IEC from NT(+) diet-fed mice produced a higher level of IL-7,which is important in the development of TCRγδ^+ IEL, than those from control diet-fed mice. The expression levels of IL-7 and IL-2 receptors on IEL were not different between the two dietary groups. Our findings suggest that the increased population of a TCRγδ^+ IEL subset by feeding nucleotides may be caused by the increased production of IL-7 by IEC.
社団法人日本農芸化学会の論文
2000-07-23