Structure-activity Relationships of Flavonoids and the Induction of Granulocyticor Monocytic-Differentiation in HL60 Human Myeloid Leukemia Cells
スポンサーリンク
概要
- 論文の詳細を見る
The flavones apigenin and luteolin strongly inhibited the growth of HL60 cells and induced morphological differentiation into granulocytes. The flavonol quercetin inhibited the cell growth and induced a differentiation marker, i.e., NBT reducing ability. However quercetin-treated cells were not morphologically differentiated into granulocytes. The chalcone phloretin weakly induced NBT reducing ability and a marker of monocytic differentiation α-naphthyl butyrate esterase activity in the cells. Quercetin and phloretin appeared to induce the differentiation of HL60 cells into monocytes. The proportion of α-naphthyl butyrate esterase-positive cells induced by genistein was less than that of the NBT-positive cells. Some of the nuclei in genistein-treated HL60 cells morphologically changed. Genistein must have induced both granulocytic and monocytic differentiation of HL60 cells. The flavonols galangin and kaempferol, which had fewer hydroxyl group (S) in the B-ring than quercetin, and the flavanone naringenin inhibited the growth but not induce the differentiation of HL60 cells.
- 社団法人日本農芸化学会の論文
- 1998-11-23
著者
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Takahashi T
Department Of Sustainable Resource Science Faculty Of Bioresources Mie University
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SHINMOTO Hiroshi
National Food Research Institute
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Hirose S
Tokachi‐ikeda Research Inst. Viticulture And Enology Hokkaido Jpn
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Tsushida T
National Food Res. Inst. Tsukuba Jpn
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Tsushida Tojiro
National Food Research Institute
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Tsushida Tojiro
National Research Institute Of Vegetables Ornamental Plants And Tea Department Of Tea Processing Tec
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KOBORI Masuko
National Food Research Institute, National Agriculture and Food Research Organization
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Shinmoto H
Snow Brand Milk Products Co. Ltd. Kawagoe Jpn
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Kobori M
National Food Research Institute
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TAKAHASHI Tohru
Iwate Industrial Research Institute
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Tsushida Tojiro
National Food Res. Inst. Tsukuba Jpn
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Kobori Masuko
National Food Research Institute
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