Continuous Orally Administered Coffee Enhanced the Antigen-Specific Th1 Response and Reduced Allergic Development in a TCR-Transgenic Mice Model
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概要
- 論文の詳細を見る
Coffee is a globally consumed beverage. Although recent studies have suggested that coffee reduced the risk of lifestyle-related diseases, there are few studies regarding allergic response.This study investigates the effects of orally administered coffee (91 ml/kg/d) on allergic responses using a T cell receptor (TCR)-transgenic DO11.10 mouse allergic model. Splenocytes from coffee-administered naïve mice increased antigen (Ag)-specific interleukin (IL)-12p40 secretion. When Ag sensitization and coffee administration were concurrently performed, the splenocytes from coffee-administered mice showed a decrease of IL-2 and an increase of IL-12p40 secretion. The Ag-specific cutaneous response and serum IgE level were reduced in coffee-administered mice, although, after establishing the allergy, coffee administration did not suppress the allergic reaction.These results suggest that coffee could induce a Th1-type response of the immune system and prevent an allergy developing. Further studies on the optimum dose, cultivar differences, and roasted degree need to be undertaken.
- 社団法人 日本農芸化学会の論文
- 2009-11-23
著者
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GOTO Masao
National Agriculture and Food Research Organization National Food Research Institute
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SHINMOTO Hiroshi
National Food Research Institute
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Hirose S
Tokachi‐ikeda Research Inst. Viticulture And Enology Hokkaido Jpn
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Shinmoto H
Snow Brand Milk Products Co. Ltd. Kawagoe Jpn
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YAMAKI Kohji
National Agricultual Research Center for Tohoky Region
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Yamaki Kohji
National Agriculture And Food Res. Organization National Food Res. Inst.
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TAKANO ISHIKAWA
National Agriculture and Food Research Organization National Food Research Institute
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Goto M
National Agriculture And Food Research Organization National Food Research Institute
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Goto Masao
農業･食品産業技術総合研究機構食品総合研究所
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