Continuous Orally Administered Coffee Enhanced the Antigen-Specific Th1 Response and Reduced Allergic Development in a TCR-Transgenic Mice Model
スポンサーリンク
概要
- 論文の詳細を見る
Coffee is a globally consumed beverage. Although recent studies have suggested that coffee reduced the risk of lifestyle-related diseases, there are few studies regarding allergic response.This study investigates the effects of orally administered coffee (91 ml/kg/d) on allergic responses using a T cell receptor (TCR)-transgenic DO11.10 mouse allergic model. Splenocytes from coffee-administered naïve mice increased antigen (Ag)-specific interleukin (IL)-12p40 secretion. When Ag sensitization and coffee administration were concurrently performed, the splenocytes from coffee-administered mice showed a decrease of IL-2 and an increase of IL-12p40 secretion. The Ag-specific cutaneous response and serum IgE level were reduced in coffee-administered mice, although, after establishing the allergy, coffee administration did not suppress the allergic reaction.These results suggest that coffee could induce a Th1-type response of the immune system and prevent an allergy developing. Further studies on the optimum dose, cultivar differences, and roasted degree need to be undertaken.
- 社団法人 日本農芸化学会の論文
著者
-
GOTO Masao
National Agriculture and Food Research Organization National Food Research Institute
-
TAKANO-ISHIKAWA Yuko
National Agriculture and Food Research Organization National Food Research Institute
-
SHINMOTO Hiroshi
National Food Research Institute
-
YAMAKI Kohji
National Agricultual Research Center for Tohoky Region
関連論文
- An in Vitro Effect of Coffee on the Antigen-Specific Immune Responses of Naïve Splenocytes
- Elevation of Intracellular cAMP Levels by Dominant Active Heterotrimeric G Protein Alpha Subunits ScGP-A and ScGP-C in Homobasidiomycete, Schizophyllum commune
- Antigenicity Estimation of Collagenase-Treated Gelatins by a Novel Assay System Using Human Antibodies Secreted by B-Lymphoblastoid Cells
- Microbial Extracellular Glycolipid Induction of Differentiation and Inhibition of the Protein Kinase C Activity of Human Promyelocytic Leukemia Cell Line HL60
- Effects of Isothiocyanates on Tumor Necrosis Factor-α Production by J774A. 1 (BALB/c macrophage) Cells
- Progressive Effects of Phloridzin on Melanogenesis in B16 Mouse Melanoma Cells
- Effect of Ginsenosides and Red Ginseng Water Extract on Tumor Necrosis Factor-α Production by Rat Peritoneal Macrophages
- Mioga (Zingiber mioga Rosc.) Extract Prevents 3T3-L1 Differentiation into Adipocytes and Obesity in Mice
- Effect of Flavonoids on the Differentiation of 3T3-L1 Adipocytes
- Flavonoids Inhibit Cell Growth and Induce Apoptosis in B16 Melanoma 4A5 Cells
- Phloretin-induced Apoptosis in B16 Melanoma 4A5 Cells and HL60 Human Leukemia Cells
- Structure-activity Relationships of Flavonoids and the Induction of Granulocyticor Monocytic-Differentiation in HL60 Human Myeloid Leukemia Cells
- Analysis of Rice Proteins of Transgenic Rice Resistant to Rice Stripe Virus
- Proanthocyanidins from Barley Bran Potentiate Retinoic Acid-induced Granulocytic and Sodium Butyrate-induced Monocytic Differentiation of HL60 Cells
- Competitive ELISA of Bovine Lactoferrin with Bispecific Monoclonal Antibodies
- Effect of caffeine on antigen-specific immune responses of mouse splenocytes
- Continuous Orally Administered Coffee Enhanced the Antigen-Specific Th1 Response and Reduced Allergic Development in a TCR-Transgenic Mice Model
- 5α,8α-Epidioxy-22E-ergosta-6,9(11),22-trien-3β-ol from an Edible Mushroom Suppresses Growth of HL60 Leukemia and HT29 Colon Adenocarcinoma Cells(Highlighted paper selected by Editor-in-chief,Pharmacognosy)
- Salicylic Acid and a Chitin Elicitor Both Control Expression of the CAD1 Gene Involved in the Plant Immunity of Arabidopsis.
- Continuous Orally Administered Coffee Enhanced the Antigen-Specific Th1 Response and Reduced Allergic Development in a TCR-Transgenic Mice Model
- Orally Administered Bisphenol A Disturbed Antigen Specific Immunoresponses in the Naïve Condition
- Mac1 Positive Cells Are Required for Enhancement of Splenocytes Proliferation Caused by Bisphenol A
- Assessment of the Mutagenicity of Extracts of TMV-Coat-Protein-Gene Induced Transgenic Tomato by the umu-Test
- Comparative Effects of Non-Gelatinized Corn and Rice Starches on the Life-Span of ICR Mice
- An in Vitro Effect of Coffee on the Antigen-Specific Immune Responses of Naive Splenocytes
- Total Degradation of Pentachloroethane by an Engineered Alcaligenes Strain Expressing a Modified Camphor Monooxygenase and a Hybrid Dioxygenase
- Enrichment and Characterization of a Trichloroethene-Dechlorinating Consortium Containing Multiple "Dehalococcoides" Strains
- Coumarin and Flavone Derivatives from Estragon and Thyme as Inhibitors of Chemical Mediator Release from RBL-2H3 Cells
- Effect of Dietary Fat on Total Mercury Content, Antioxidative Factors, and Lipid Profile in Adult Mice Exposed to Low Levels of Methylmercury
- Effect of Lacto-N-biose I on the Antigen-specific Immune Responses of Splenocytes
- Eggplant Extract Inhibits Melanogenesis in B16 Melanoma Cells.