Orally Administered Bisphenol A Disturbed Antigen Specific Immunoresponses in the Naïve Condition
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概要
- 論文の詳細を見る
Bisphenol A [2,2-bis(4-hydoxyphenyl)propane; BPA] is an endocrine disrupter widely used in polycarbonate plastics and epoxy resins. We investigated the effects of orally administered BPA on antigen-specific responses of the naïve immune system.BPA was orally administered to T cell receptor transgenic mice, and the antigen-specific responses of immune cells were investigated. Administered BPA moderately reduced interleukin (IL)-2, 4, and interferon (IFN)-γ secretion and increases in IgA and IgG2a production.Additionally, it was found that orally administered BPA increased antigen-specific IFN-γ production of T cells and modified whole antigen presenting cells (APCs) to suppress antigen-specific cytokine production from T cells.These findings suggest that BPA can augment the Th1-type responses of naïve immune systems, though the bioavailability of orally administered BPA was low in our experiments.
- 社団法人 日本農芸化学会の論文
著者
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YOSHIDA Mitsuru
National Food Research Institute
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ONO Hiroshi
National Food Research Institute
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GOTO Masao
National Agriculture and Food Research Organization National Food Research Institute
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TAKANO-ISHIKAWA Yuko
National Agriculture and Food Research Organization National Food Research Institute
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Asada Yutaka
Division Of Biological Sciences Graduate School Of Science Hokkaido University
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Takano-ishikawa Yuko
National Agriculture And Food Res. Organization National Food Res. Inst.
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SHINMOTO Hiroshi
National Food Research Institute
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YAMAKI Kohji
Japan International Research Center for Agricultural Sciences
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Ono Hiroshi
National Agriculture And Food Research Organization National Food Research Institute
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Yoshida Mitsuru
National Agriculture And Food Research Organization National Food Research Institute
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