Isolation and Structural Determination of Makinolide B from Streptomyces sp. MK-19
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概要
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A new 16-membered macrolide named makinolide B (1) was isolated from Streptomyces sp. MK-19. The structure of makinolide B (1) was determined on the basis of 2D NMR experiments involving DQF-COSY, TOCSY, HSQC, and HMBC methods. Application of the paper disk diffusion method to makinolide B (1) showed weak antibacterial activity against Staphylococcus aureus at the dose of 100 µg/disk.
著者
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KODANI Shinya
Graduate School of Science and Technology, Shizuoka University
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Yoshida Mitsuru
National Agriculture And Food Research Organization National Food Research Institute
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HIDAKI Michitaka
Graduate School of Agriculture, Shizuoka University
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OGAWA Naoto
Graduate School of Agriculture, Shizuoka University
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