Microbial Extracellular Glycolipid Induction of Differentiation and Inhibition of the Protein Kinase C Activity of Human Promyelocytic Leukemia Cell Line HL60

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概要

• 論文の詳細を見る

• The biological activities of 7 microbial extracellular glycolipids including mannosylerythritol lipid (MEL)-A, MEL-B, polyol lipid (PL), rhamnolipid (RL), sophorose lipid (SL), succinoyl trehalose lipid (STL)-1, and STL-3 were investigated. All glycolipids except for RL were found to induce cell differentiation instead of cell proliferation in the human promyelocytic leukemia cell line HL60. To identify the differentiation direction of the induced cells, the leukocyte esterase activities were cytologically investigated, and the results showed that MEL-A, MEL-B, and PL induced HL60 to differentiate into granulocytes, while SL, STL-1, and STL-3 induced differentiation into monocytes. The 6 effective glycolipids also increased nitroblue tetrazolium (NBT) reducing ability, which is a common differentiation-associated characteristic in monocytes and granulocytes. Furthermore, it was also observed that these 6 glycolipids inhibited the activity of phospholipid- and Ca^<2+> -dependent protein kinase. Additionally, the 6 effective glycolipids also induced the human myelogenous leukemia cell line K562 and the human basophilic leukemia cell line KU812 to differentiate into monocytes, granulocytes, and megakaryocytes.

• 社団法人日本農芸化学会の論文
• 1997-04-23

著者

• Kitamoto D

  Research Institute For Green Technology National Institute Of Advanced Industrial Science And Techno

• Isoda H

  Univ. Tsukuba Ibaraki Jpn

• Isoda H

  Snow Brand Milk Products Co. Kawagoe Jpn

• Isoda Hiroko

  Technical Research Institute Snow Brand Milk Products Co.

• Isoda Hiroko

  Institute Of Applied Biochemistry University Of Tsukuba

• MATSUMURA Masatoshi

  Institute of Applied Biochemistry, University of Tsukuba

• Nakahara Tadaatsu

  Institute of Applied Biochemistry, University of Tsukuba

• Kitamoto Dai

  National Institute Of Advanced Industrial Science And Technology

• Kitamoto Dai

  National Institute Of Advanced Industrial Science And Technology (aist)

• Kitamoto Dai

  National Chemical Laboratory For Industry

• SHINMOTO Hiroshi

  National Food Research Institute

• Nakahara T

  Institute Of Applied Biochemistry University Of Tsukuba:(present Address)ryutsu Keizai University

• Nakahara Tadaatsu

  Institute Of Applied Biochemistry University Of Tsukuba

• Matsumura M

  Graduate School Of Life And Environmental Science University Of Tsukuba

• Matsumura Masatoshi

  Institute Of Applied Biochemistry University Of Tsukuba

• Matsumura M

  Graduate School Of Agriculture University Of Tsukuba

• Matsumura Masatoshi

  Agricultual Sciences University Of Tsukuba

• MOTOBU Maki

  National Institute of Animal Health

• Nakahara Tadaatsu

  Institute Of Applied Biochemistry The University Of Tsukuba

• Matsumura Masatoshi

  Institute Applied Biochemisry Tsukuba University

• Shinmoto Hiroshi

  National Food Research Institute Ministry Of Agriculture Forestry And Fsheriesinstitute Of Applied B

• Isoda Hiroko

  Institute of Agricultural and Forest Engineering, University of Tsukuba:(Present address)Research Center for Material Cycles and Waste Management, National Institute for Environmental Studies

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