Inhibitory Effects of Bovine Lactoferrin on the Adherence of Enterotoxigenic Escherichia coli to Host Cells
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概要
- 論文の詳細を見る
Adherence is an essential and prerequisite step for the colonization of mucosal surfaces by enterotoxigenic Escherichia coli (ETEC). We studied the effect of bovine lactoferrin (BLF) on the adherence of ETEC to human epithelial cells in vitro, and to intestinal mucosa of ICR germfree mice in vivo. In the in vitro study, BLF was found to inhibit the adherence of ETEC. This adhesion-inhibiting activity of BLF was found to lessen with decreasing BLF concentration, but the data obtained suggest a positive inhibitory effect of BLF against the adhesion of ETEC cells. In the in vivo study, the counts of adherent bacteria in various sections of the intestinal tract (duodenum, jejunoileum, and large intestine) were lower in the BLF group than in the control group, suggesting the possible action of BLF as an intestinal tract adherence-blocking agent with regards to ETEC.
- 社団法人日本農芸化学会の論文
- 2000-02-23
著者
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KAWASAKI Yoshihiro
Technology and Research Institute, Snow Brand Milk Products Co., Ltd.
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Isoda H
Univ. Tsukuba Ibaraki Jpn
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Isoda H
Snow Brand Milk Products Co. Kawagoe Jpn
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Isoda Hiroko
Technical Research Institute Snow Brand Milk Products Co.
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Matsuzawa Hideyuki
Tokai University School Of Health Sciences
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Kawasaki Yoshihiro
Technical Research Institute Snow Brand Milk Products Co. Ltd.
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Kawasaki Yoshihiro
Technical Research Institute Snow Brand Milk Products Co.
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Kawasaki Y
Snow Brand Milk Products Co. Ltd. Saitama Jpn
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Shimizu K
Department Of Forest Products Faculty Of Agriculture Kyushu University
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TAZUME Seiki
Tokai University School of Health Sciences
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SHIMIZU Keiko
Tokai University School of Health Sciences
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DOSAKO Shunichi
Technical Research Institute, Snow Brand Milk Products Co.
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TSUKIJI Mami
Kanagawa Prefectural College of Medical Technology
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FUJIMURA Ryuko
Tokai University School of Health Sciences
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MURANAKA Yoko
Tokai University School of Health Sciences
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ISIHIDA Hiroshi
Junior College, Tokyo University of Agriculture
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Tazume S
Tokai University School Of Health Sciences
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Shimizu Kumi
Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku University
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Dosako Shunichi
Technical Research Institute Snow Brand Milk Products Co.
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