Analysis of Antiviral Resistance in the Intestinal Tracts of Nude Mice Infected with a Mouse Adenovirus

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Upon intestinal infection of heterozygous (nu/+) mice with mouse adenovirus, antiviral resistance can be seen in the form of negative-recovery of virus from feces 2-3 wks post infection. On the other hand, in similar infections in BALB/c nude (nu/nu) mice, the antiviral resistance is manifested as negative-recovery of virus from feces at a later stage, i. e., at around 6 wks post infection. This resistance was not accompanied by rises in interferon titer, rises in natural killer (NK) cell activity, nor was the resistance affected by the introducion of anti-asialo GM1 antibody. No distinct loss of resistance was observed upon administration of carrageenan, but the resistance in the group given carrageenan immediately before and after viral challenge seemed to be slightly reduced. In all infected nu/nu mice, neither neutralizing antibody (NT-Ab) nor complement-dependent NT-Ab could be detected by the usual tube method. On the other hand, a complete abolishment of the antiviral resistance was seen following cyclophosphamide administration. For clarification of the antiviral resistance factor in nu/nu mice, the analysis of antibody other than NT-Ab and complement-dependent NT-Ab, and the problem of resolution of antibody titration remain. Furthermore, it has been noted that the serum IgG titer is high in nu/nu mice and that this level is depressed by cyclophosphamide administration. It is believed that this may be in some way involved with the loss of antiviral resistance observed.
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