Cyclic AMP and Immune Responses: Identification of Prostaglandin E-Producing Cells in Mouse Spleens
スポンサーリンク
概要
- 論文の詳細を見る
Previous work has shown that normal mice respond to the intravenous injection of sheep erythrocytes (SRBC) with a transient increase in splenic cyclic AMP peaking after 2 minutes, and this cyclic AMP response has been shown to be due to prostaglandins (PGs) released from antigen-specific cells. In the present study, the cell type responsible for PG production in response to antigen was determined using a fluorescence-activated cell sorter (FACS) and an electron microscope. C57B1/6 mice injected with SRBC showed a 2% increase of PGE-producing spleen cells relative to controls. In control mice injected with phosphate-buffered saline (PBS), 19% of the spleen cells produced PGE. An electron microscopic study of PGE-producing cells sorted on FACS showed that they were small lymphocytes and plasma cells. In addition, nude mice also increased the number of PGE-producing spleen cells in response to antigen. These findings suggest that lymphocytes involving at least B-cells respond to antigen with an increase in PGE production.
- 東海大学の論文
著者
-
SASAKI Shogo
Department of Microbiology, School of Medicine, Tokai University
-
HASHIMOTO Kazuo
Department of Microbiology, School of Medicine, Tokai University
-
Hashimoto Kazuo
Department Of Microbiology School Of Medicine Tokai University
-
SHIMAMURA Tadakatsu
Department of Microbiology and Immunology, Showa University School of Medicine
-
Sasaki Shogo
Department Of Infectious Disease Tokai University School Of Medicine Isehara
-
SASADAIRA Hidekazu
Department of Pathology, School of Medicine, Tokai University
-
TSURU Sumiaki
Department of Bacteriology, National Defense Medical College
-
ZINNAKA Yutaka
Department of Bacteriology, National Defense Medical College
-
Shimamura Tadakatsu
Department Of Microbiology School Of Medicine Tokai University
-
Shimamura Tadakatsu
Department Of Bacteriology And Immunology Showa University School Of Medicine
-
Tsuru Sumiaki
Department Of Bacteriology National Defense Medical College
-
Zinnaka Yutaka
Department Of Bacteriology National Defense Medical College
-
Sasadaira Hidekazu
Department Of Pathology School Of Medicine Tokai University
-
SASAKI SHOGO
Department of Bacteriology, School of Medicine, Keio University
関連論文
- Comparison of Protected Isolation Techniques between the Laminar Airflow Room and the Life Island Unit
- Septicemia during Compromised Host Treated in a Protected Isolation Unit
- Bacteriological Evaluation of an Isolation Ward during Patient Occupancy
- The Utility of Protective Environment and Prophylactic Antibiotics in the Therapy of Leukemia
- The Level of Purification and Sterilization Methods in the Bioclean Room
- Trial of Isolation of a Virus from Sera of Patients with Kawasaki Disease
- The role of the intestinal bacterial flora in the neonal period for establishing the oral tolerance in the adult
- Participation of CD14 in the Phagocytosis of Smooth-Type Salmonella typhimurium by the Macrophage-Like Cell Line, J774.1
- Calcium Induced Differentiation of SV40 Immortalized Human Epidermal Keratinocytes Cultured in a Defined Medium
- A RAPID MICROASSAY FOR HEMOLYTIC ANTIBODY : ITS APPLICATION TO IMMUNOTOXICOLOGICAL STUDY
- Immunological Effects of Arsenic Compounds on Mouse Spleen Cells in vitro
- Concurrent Murine Cytomegalovirus and Klebsiella pneumoniae Infections in Germfree Mice
- Immunological Responses in Germfree Mice Infected with Murine Cytomegalovirus
- Different susceptibilities of Staphylococcus and Gram-negative rods to epigallocatechin gallate
- Inhibition by epigallocatechin gallate (EGCg) of conjugative R plasmid transfer in Escherichia coli
- Gastrointestinal Decontamination in the Compromised Host and its Clinical Significance
- Murine Cytomegalovirus Infection Model in Balb/c Mice : 3. Immunoglobulin Production during Infection
- Murine Cytomegalovirus Infection Model in Balb/c Mice : 2. Pericarditis with Myocardial Involvement during Virus Infection
- Murine Cytomegalovirus Infection Model in Balb/c Mice : 1. Virological and Pathological Profiles in Mice Inoculated with Various Virus Doses
- ON n-TH VON NEUMANN-JORDAN CONSTANTS FOR BANACH SPACES
- Generalized Clarkson's Inequalities for Lebesgue-Bochner Spaces
- Ecological Investigation on Intestinal Bacterial Flora of Patients Nursed in Protected Environmental Units
- The Germfree Ward of Tokai University Hospital
- Isolation rate of non-hemagglutinating strains of Serratia marcescens from clinical specimens in a general hospital : comparison of serotypes O2 and O14
- Cyclic AMP and Immune Responses: Identification of Prostaglandin E-Producing Cells in Mouse Spleens
- Antigenic Competition : Suppression of the Response to a First Antigen by a Second Antigen
- Cyclic AMP and Immune Responses : Cytochemical Identification and Localization of Adenylate Cyclase Responding Cells in Antigen-Stimulated Mouse Spleen
- Analysis of Antiviral Resistance in the Intestinal Tracts of Nude Mice Infected with a Mouse Adenovirus
- Normalization of Reproductive Function in Germfree Mice Following Bacterial Contamination
- Immunomodulatory Effect of Gold Sodium Thiomalate on Murine Acquired Immunodeficiency Syndrome
- A Case Report of Intestinal Myiasis
- Structural Requirements of Cholesterol for Binding to Vibrio cholerae Hemolysin
- Selection of Hypotoxigenic Vibrio cholerae Population by Human Intestinal Bacteria in Gnotobiotic Mice
- Molecular Properties of Cholera Enteroxin
- The Role of Cyclic AMP in the Immune Response
- THE RELATIONSHIP BETWEEN MORTALITY OF STROKE AND TRACE METAL ELEMENTS
- Interaction between Host and Intestinal Normal Bacterial Flora
- Experimental Analysis of Concurrent Viral and Bacterial Infection in the Mouse
- IMMUNE RESPONSE IN GERMFREE MICE ORALLY IMMUNIZED WITH VIBRIO CHOLERAE
- INFECTIVITY IN ORAL INFECTION OF MICE WITH SALMONELLA ENTERITIDIS: EFFECT OF STREPTOMYCIN ON THE INFECTIVITY WITH SPECIAL REFERENCE TO NORMAL INTESTINAL FLORA
- MONOASSOCIATION WITH BACTERIA IN THE INTESTINES OF GERMFREE MICE
- EARLY FEATURES OF INFECTION IN LIGATED LOOPS OF THE RABBIT SMALL INTESTINE INOCULATED WITH SHIGELLA FLEXNERI 3a, ENTEROPATHOGENIC E. COLI, ESCHERICHIA COLI AND VIBRIO PARAHAEMOLYTICUS:THE FIRST REPORT: VARIATION OF BACTERIAL POPULATION SIZE IN LIGATED LOO
- EARLY FEATURES OF INFECTION IN LIGATED LOOPS OF THE RABBIT SMALL INTESTINE INOCULATED WITH SHIGELLA FLEXNERI 3a, ENTEROPATHOGENIC E. COLT, ESCHERICHIA COLT AND VIBRIO PARAHAEMOLYTICUS:THE SECOND REPORT: GROSS APPEARANCE AND HISTOLOGICAL FINDINGS OF LIGATE
- COMPARISON OF SEVERAL PURIFICATION METHODS FOR TUBERCULIN PROTEIN