Effect of Flavonoids on the Differentiation of 3T3-L1 Adipocytes
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概要
- 論文の詳細を見る
The effect of dietary flavonoids (flavone, isoflavone, flavanone, chalcone, flavonol, and flavonol derivatives) on the differentiation of 3T3-L1 adipocytes was investigated. Glycerol-3-phosphate dehydrogenase (GPDH) activity, which is a hallmark of 3T3-L1 differentiation, was measured. The GPDH activity in the cells treated with quercetin, kaempferol, and isorhamnetin was significantly lower than that in the control cells. A low lipid accumulation in cells stained with Oil-Red O was observed following treatment of these flavonols. The anti-differentiation action of quercetin was more potent than that of its derivatives. Quercetin directly inhibited the activity of GPDH extracted from mature 3T3-L1 adipocytes. The inhibitory action of quercetin on the differentiation of 3T3-L1 cells may involve the direct inhibition of GPDH, which is a key enzyme lipid synthesis.
- 社団法人 日本食品科学工学会の論文
- 2001-05-01
著者
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Takahashi T
Department Of Sustainable Resource Science Faculty Of Bioresources Mie University
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Tsushida T
National Food Res. Inst. Tsukuba Jpn
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Tsushida Tojiro
National Food Research Institute
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Tsushida Tojiro
National Research Institute Of Vegetables Ornamental Plants And Tea Department Of Tea Processing Tec
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YAMAKI Kohji
National Agricultual Research Center for Tohoky Region
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IWASHITA Keiko
Institute of Applied Biochemistry, University of Tsukuba
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Yamaki K
National Agricultual Res. Center For Tohoku Region Fukushima Jpn
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Isshiki K
Institute Of Applied Biochemistry University Of Tsukuba
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Tsushida Tojiro
National Food Res. Inst. Tsukuba Jpn
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