Antihypertensive Effect of Enzyme-Treated Zein in Stroke-Prone Spontaneously Hypertensive Rats
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概要
- 論文の詳細を見る
Zein was treated by thermolysin and Proleather, the latter a mixture of proteinases from Bacillus sp. The corresponding products were called SD-ZT and DA-Pro, respectively, The hydrolysates resulting from 2 h-hydrolysis by thermolysin and Proleather showed the strongest ACE inhibitory activity, and the IC50 values were 6.5 and 7.5 μg/μl, respectively. Effects of the administration of zein hydrolysates from thermolysin and Proleather on the systolic blood pressures (SBPs) were studied in SHRSP. Intragastric administration of SD-ZT and DA-Pro showed a significant decrease in the SBP at 6 and 24 h. Experimental diets were prepared by mixing 5% (w/w) of SD-ZT or DA-Pro with the control diet and were fed ad libitum to SHRSP for 5 weeks. In comparison with the control group, the elevation of blood pressure of SHRSP fed the SD-ZT diet or DA-Pro diet was suppressed from the 9th day after administration. The serum ACE activities in the DA-Pro group were lower than those in the SD-ZT group and the control group.
- 社団法人 日本食品科学工学会の論文
- 2000-02-01
著者
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TAKAHASHI Takao
Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute
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Takahashi T
Department Of Sustainable Resource Science Faculty Of Bioresources Mie University
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Tsushida T
National Food Res. Inst. Tsukuba Jpn
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Tsushida Tojiro
National Research Institute Of Vegetables Ornamental Plants And Tea Department Of Tea Processing Tec
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Furuichi Yukio
Laboratory of Nutrition Chemistry, Department of Agricultural Chemistry, Faculty of Bioresources, Mi
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Umekawa Hayato
Laboratory of Nutrition Chemistry, Department of Agricultural Chemistry, Faculty of Bioresources, Mi
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Furuichi Y
Faculty Of Bioresouces Mie University
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Furuichi Yukio
Laboratory Of Nutrition Chemistry Department Of Agricultural Chemistry Faculty Of Bioresources Mie U
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Umekawa H
Mie Univ. Tsu Jpn
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Umekawa Hayato
Department Of Agricultural Chemistry Faculty Of Bioresources Mie University
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Doi Umeyuki
R&d Department San-ei Sugarochemical Co. Ltd.
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Ukawa Yuuichi
Laboratory Of Nutritional Chemistry Department Of Agricultural Chemistry Faculty Of Bioresources Mie
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XU Xianwei
Laboratory of Nutritional Chemistry, Department of Agricultural Chemistry, Faculty of Bioresources,
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DOI Umeyuki
R&D Department, San-ei Sugarochemical Co., Ltd.
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SHIBATA Masahiko
R&D Department, San-ei Sugarochemical Co., Ltd.
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FUNATSU Gunki
Emeritus Professor of Kyushu University
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Xu Xianwei
Laboratory Of Nutritional Chemistry Department Of Agricultural Chemistry Faculty Of Bioresources Mie
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Takahashi Takao
Laboratory Of Nutritional Chemistry Department Of Agricultural Chemistry Faculty Of Bioresources Mie
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Shibata Masahiko
R&d Department San-ei Sugarochemical Co. Ltd.
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Takahashi Takao
Laboratory Of Nutrition Chemistry Department Of Agricultural Chemistry Faculty Of Bioresources Mie U
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