β-1,3-Glucan Attenuates Neuronal Cell Death after Transient Retinal Ischemia and Reperfusion

スポンサーリンク

概要

• 論文の詳細を見る

• The neuroprotective effect of intravitreally injected β-1,3-glucan was examined in a rat model of transient retinal ischemia. Retinal function and morphology were assessed in both control rats (Intact), and in rats administered β-1,3-glucan after ischemic damage induced by elevation of intraocular pressure (IOP) to 130 mmHg for 45 min. β-1,3-Glucan was intravitreally injected into male SD rats, with a final vitreal concentration of 5 µg/eye. Retinal function was assessed by electroretinography, and retinal morphology was assessed by light microscopy and TUNEL assay (n = 3 for Intact, and n = 6 for β-1,3-glucan and Vehicle). Morphometric analysis of retinal ganglion cells (RGCs) and the inner plexiform layer (IPL) showed decreased RGC number and thinner IPL in the eyes of Intact rats compared with those injected with β-1,3-glucan. TUNEL assay results showed that the retinas of eyes injected with β-1,3-glucan were similar to those of Intact eyes (the left eyes of the SD rats). However, the retinas of Vehicle eyes differed in RGC and IPL layer from β-1,3-glucan injected eyes after transient retinal ischemia. Electroretinograms (ERGs) showed that the β-1,3-glucan-administered rats had significantly more protective b-wave amplitudes compared with the Vehicle group. β-1,3-Glucan exhibits a neuroprotective effect in a transient retinal ischemia model of retinal injury in rats.

著者

• Uji Yukitaka

  Department Of Ophthalmology Faculty Of Medicine Mie University

• ISONO NAOTO

  Department of Applied Bioscience, Graduate School of Agriculture, Hokkaido University

• Umekawa Hayato

  Department Of Agricultural Chemistry Faculty Of Bioresources Mie University

• Isono Naoto

  Department Of Applied Bioscience Graduate School Of Agriculture Hokkaido University

• Nishio Masahiro

  Department Of Agricultural Chemistry Faculty Of Bioresources Mie University

• ISONO Naoto

  Department of Sustainable Resource Science, Graduate School of Bioresources, Mie University

• KUMITA Yusuke

  Department of Sustainable Resource Science, Graduate School of Bioresources, Mie University

• UMEKAWA Hayato

  Department of Sustainable Resource Science, Graduate School of Bioresources, Mie University

• UJI Yukitaka

  Department of Ophthalmology, Graduate School of Medicine, Mie University

関連論文

• Supraciliochoroidal Fluid at an Early Stage After Trabeculectomy
• Cloning and Heterologous Expression of a β-Fructofuranosidase Gene from Arthrobacter globiformis IFO 3062, and Site-Directed Mutagenesis of the Essential Aspartic Acid and Glutamic Acid of the Active Site (ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHN
• Purification and Characterization of a Lectin from Amaranthus hypochondriacus var. Mexico Seeds
• Some Characteristics of an Alpha-amylase Inhibitor from Phaseolus vulgaris (Cultivar Great Northern) Seeds
• Preparation of α,β-Unsaturated Methyl Ketones from Diketene Using Bis(tributyltin) Oxide
• The Carboxyl Terminal Sequence of Nucleolar Protein B23.1 Is important in Its DNA Polymerase α-Stimulatory Activity
• Biological Availability of Docosahexaenoic Acid from Fish Oil Encapsulated in Zein-Coated Porous Starch Granules in Rats
• Antihypertensive Effect of Enzyme-Treated Zein in Stroke-Prone Spontaneously Hypertensive Rats
• Nucleolar Protein B23.1 Binds to Retinoblastoma Protein and Synergistically Stimulates DNA Polymerase α Activity^1
• Effects of Castor Oil on Lipid Metabolism in Rats
• Characterization of a Lectin from the Leaves of Great Northern Bean, Phaseolus vulgaris L.
• Purification and Characterization of Three Mitogenic Lectins from the Roots of Pokeweed : (Phytolacca americana)
• Interaction of Tora-mame (Phaseolus vulgaris) Lectin with Indole Derivatives(Biological Chemistry)
• Purification and Characterization of Tora-mame (Phaseolus vulgaris) Seed Calmodulin(Biological Chemistry)
• Esterification of Ovalbumin Depresses the Nutritive Values(Food & Nutrition)
• Esterification of Ovalbumin : Effects on Solubility and Digestibility by Enzymes(Food & Nutrition)
• Tryptophans 286 and 288 in the C-terminal Region of Protein B23.1 are Important for Its Nucleolar Localization(Biochemistry & Molecular Biology)
• Double Alkylation of Tin Enolate Derived from Diketene and Bis(tributyltin) Oxide
• Contribution of Nitric Oxide-Producing Cells in Normal and Diabetic Rat Retina
• Angle Recess Area Deceases With Age in Normal Japanese
• Characterization of Starch Synthase I and II Expressed in Early Developing Seeds of Kidney Bean (Phaseolus vulgaris L.)
• Ocular Hypertelorism and Exotropia as Presenting Signs in Diamond-Blackfan Anemia
• Inducible Nitric Oxide Synthase Mediates Retinal DNA Damage in Goto-Kakizaki Rat Retina
• Time-Dependent Course of Electroretinograms in the Spontaneous Diabetic Goto-Kakizaki Rat
• Failure of Multinucleated Giant Cell Formation in K562 Cells Infected with Newcastle Disease Virus and Human Parainfluenza Type 2 Virus
• Central Retinal Vein Occlusion During Remission of Ulcerative Colitis
• Ultrasound Biomicroscopy Dark Room Provocative Testing : A Quantitative Method for Estimation Anterior Chamber Angle Width
• Symmetry Analysis for Detecting Early Glaucomatous Changes in Ocular Hypertension Using Optical Coherence Tomography
• Use of Indocyanine Green During Excision of an Overhanging Filtering Bleb
• Haloperidol Effects on Na Current in Acutely Isolated Rat Retinal Ganglion Cells
• Comparison Between Dawson, Trick, and Litzkow Electrode and Contact Lens Electrodes Used in Clinical Electroretinography
• Changes in Electroretinogram Oscillatory Potentials During Dark Adaptation
• Switch to Latanoprost Monotherapy from Combined Treatment with β-Antagonist and Other Antiglaucoma Agents in Patients with Glaucoma or Ocular Hypertension
• Heterogeneity of the morphology of growing starch granules at the developing seeds of kidney bean (Phaseolus vulgaris L. )
• A comparative study of ethanol production by Issatchenkia orientalis strains under stress conditions
• A case of developmental glaucoma suspected from megalophthalmos represented by obstetric ultrasonography
• Purification and Characterization of 1,3-β-D-Glucan Phosphorylase from Ochromonas danica
• A wild and tolerant yeast suitable for ethanol fermentation from lignocellulose(ENVIRONMENTAL BIOTECHNOLOGY)
• PepNovoとPEAKSを用いたde novoペプチド配列解析
• β-1,3-Glucan Attenuates Neuronal Cell Death after Transient Retinal Ischemia and Reperfusion
• Cellular Effects Of Tamari Soy Sauce-derived 1-[5-(Hydroxymethyl)furan-2-yl]-9H-pyrido[3,4-b]indole-3-carboxylic Acid (Flazin)
• Cellular Effects Of Tamari Soy Sauce-derived 1-[5-(Hydroxymethyl)furan-2-yl]-9H-pyrido[3,4-b]indole-3-carboxylic Acid (Flazin)

もっと見る 閉じる

スポンサーリンク