Inhibitory Effects of Apple Polyphenols on Differentiation of 3T3-L1 Cells into Adipocytes
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概要
- 論文の詳細を見る
A crude apple polyphenol (CAP) fraction partially purified from unripe apples was found to inhibit adipose differentiation in mouse fibroblast 3T3-L1 cells. CAP inhibited the increase in intracellular levels of glycerophosphate-3-dehydrogenase (GPDH), one of the most important enzymes in the pathway for triacylglycerol biosynthesis, that occurs upon differentiation of 3T3-L1 cells into adipocytes and decreased the triglyceride content of the cells. In particular, apple condensed tannins (ACT), purified from CAP, inhibited the increase in GPDH activity when these cells differentiated. In contrast, phloridzin, (+)-catechin, and (−)-epicatechin, which were also present in the CAP fraction, decreased the triglyceride content of the cells but did not inhibit the increase in GPDH activity These results suggest that ACT such as procyanidins inhibit the differentiation of preadipocytes into adipocytes.
- 社団法人 日本食品科学工学会の論文
- 2000-05-01
著者
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Kanda T
Nikka Whisky Distilling Co. Ltd. Aomori Jpn
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Takahashi T
Department Of Sustainable Resource Science Faculty Of Bioresources Mie University
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Shoji Toshiharu
Laboratory Of Molecular Gene Technics Graduate School Of Genetic Resources Technology Kyushu Univers
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Shoji Toshihiko
Fundamental Research Laboratory Asahi Breweries Ltd.
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Hirose S
Tokachi‐ikeda Research Inst. Viticulture And Enology Hokkaido Jpn
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Tsushida T
National Food Res. Inst. Tsukuba Jpn
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Tsushida Tojiro
National Food Research Institute
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Tsushida Tojiro
National Research Institute Of Vegetables Ornamental Plants And Tea Department Of Tea Processing Tec
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KOBORI Masuko
National Food Research Institute, National Agriculture and Food Research Organization
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Shinmoto H
Snow Brand Milk Products Co. Ltd. Kawagoe Jpn
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Yanagida Akio
Department Of Analytical Chemistry School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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KANDA Tomomasa
Institute for Production Research and Development, The Nikka Whisky Distilling Co., LTD.,
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YANAGIDA Akio
Institute for Production Research and Development, The Nikka Whisky Distilling Co., LTD.,
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SHOJI Toshihiko
Institute for Production Research and Development, The Nikka Whisky Distilling Co., Ltd.
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SHINMOTO Hiroshi
Tohoku National Agricultural Experiment Station, Ministry of Agriculture, Forestry, and Fisheries
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Kobori M
National Food Research Institute
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Tsushida Tojiro
National Food Res. Inst. Tsukuba Jpn
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Kobori Masuko
National Food Research Institute
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