Inhibitory Effects of Apple Polyphenol on Induced Histamine Release from RBL-2H3 Cells and Rat Mast Cells
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概要
- 論文の詳細を見る
The anti-allergic activities of polyphenol fractions extracted from immature fruits of apple (Rosaceae, Malus sp.) were evaluated by in vitro assays. A crude apple polyphenol (CAP) fraction, which had been obtained from the juice of immature apples by reverse-phase column chromatography, was further purified by LH-20 column chromatography to obtain an apple condensed tannin (ACT) fraction consisting of linear oligomeric epicatechins from the dimer to pentadecamer. ACT strongly inhibited the release of histamine from rat basophilic leukemia (RBL-2H3) cells stimulated by the antigen-stimulation and from rat peritoneal mast cells stimulated by compound 48/80. The IC_<50> values for histamine release were 30 μg/ml and 25 μg/ml, respectively. ACT also inhibited hyaluronidase activity and the increase in intracellular free calcium concentration in RBL-2H3 cells stimulated with the antigen. These results suggest that ACT Affected early signal transduction including the calcium influx.
- 社団法人日本農芸化学会の論文
- 1998-07-23
著者
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TESHIMA Reiko
National Institute of Health Sciences
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合田 幸弘
国立医薬品食品衛生研究所
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AKIYAMA Hiroshi
National Institute of Health Sciences
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Teshima R
National Inst. Of Health Sciences
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Teshima Reiko
国立医薬品食品衛生研究所 機能生化学部
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GODA Yukihiro
National Institute of Health Sciences
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TOYODA Masatake
National Institute of Health Sciences
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Saito Yukio
National Institute Of Health Sciences
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Teshima Reiko
National Institute Of Health Science
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Goda Y
National Institute Of Health Sciences
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Kanda T
Nikka Whisky Distilling Co. Ltd. Aomori Jpn
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Toyoda M
Jissen Women's Univ.
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Toyoda Masatake
Faculty Of Human Life Sciences Jissen Women's University
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Saito Y
National Institute Of Health Sciences
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Goda Yukihiro
National Inst. Of Health Sciences
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Tanabe Masayuki
Institute For Production Research And Development The Nikka Whisky Distilling Co. Ltd.
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Teshima Reiko
National Inst. Of Health Sciences
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Yanagida Akio
Department Of Analytical Chemistry School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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KANDA Tomomasa
Institute for Production Research and Development, The Nikka Whisky Distilling Co., LTD.,
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YANAGIDA Akio
Institute for Production Research and Development, The Nikka Whisky Distilling Co., LTD.,
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Takeda Mitsuharu
College Of Bioresource Sciences Nihon University
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Akiyama Hiroshi
National Food Research Institute National Agriculture And Food Research Organization
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TANABE Masayuki
Institute for Production Research and Development, The Nikka Whisky Distilling Co., Ltd.
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