The Feeding of β-Carotene Down-Regulates Serum IgE Levels and Inhibits the Type I Allergic Response in Mice(Highlighted paper selected By Editor-in-chief)(Analytical Biochemistry)
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概要
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Feed containing β-carotene was administered orally to BALB/c mice immunized intraperitoneally with ovalbumin (OVA) for approximately 1 month. The titers of OVA-specific IgE, OVA-specific IgG1 and OVA-specific IgG2a in the mouse sera were determined. The OVA-specific IgE titer and OVA-specific IgG1 titer by mice fed β-carotene were significantly inhibited. On the other hand, the OVA-specific IgG2a titer in mice fed β-carotene was significantly greater than those of control mice. The OVA-specific IgE suppression of β-carotene feeding was dose-dependent. We also examined the effect of fed β-carotene on active systemic anaphylaxis. Feeding β-carotene to mice immunized with OVA inhibited the immediate reduction of the body temperature induced by antigen stimulation. Furthermore, the increase in serum histamine in the mice fed β-carotene under active systemic anaphylaxis was lower than in controls. We then examined the pattern of cytokine production by spleen cells from mice followed by restimulation with OVA in vitro. The spleen cells from the mice fed β-carotene produced more IFN-γ, IL-12 and IL-2 than those from the control group. In contrast, the spleen cells from the mice fed β-carotene produced less IL-4, IL-5, IL-6, IL-10 than those from the control group. Furthermore, analysis of IFN-γ mRNA levels of the splenocytes using the real-time quantitative RT-PCR technique revealed higher levels in the splenocytes from the mice fed β-carotene. These findings suggest that feeding β-carotene improves the helper T cell (T_H)1-T_H2 balance, inhibiting specific IgE and IgG1 production and antigen-induced anaphylactic response.
- 社団法人日本薬学会の論文
- 2004-07-01
著者
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Maitani Tamio
国立医薬品食品衛生研究所
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Maitani Tamio
National Institute of Health Sciences
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合田 幸弘
国立医薬品食品衛生研究所
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AKIYAMA Hiroshi
National Institute of Health Sciences
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Maitani Tamio
Division of Foods, National Institute of Health Sciences
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GODA Yukihiro
National Institute of Health Sciences
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WATANABE Takahiro
National Institute of Health Sciences
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Sato Y
Division Of Food National Institute Of Health Sciences
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Goda Y
National Institute Of Health Sciences
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Nagaoka Megumi
National Institute Of Health Sciences
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INAKUMA Takahiro
Research Institute, Kagome Co., Ltd.,
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Maitani T
Division Of Foods National Institute Of Health Sciences
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SATO Yuji
National Institute of Health Sciences
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SUGANUMA Hiroyuki
Research Institute, Kagome Co., LTD.
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Sakano Yuichi
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Goda Yukihiro
National Inst. Of Health Sciences
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Takagi Miyuki
Faculty Of Pharmacy Chiba Institute Of Science
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Machiguchi Takahisa
Faculty Of Science Saitama University
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Maitani Tamio
National Institute For Environmental Studies
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Inakuma T
Kagome Co. Ltd.
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Inakuma Takahiro
Res. Inst. Kagome Co. Ltd.
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Suganuma H
Research Institute Kagome Co. Ltd.
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Suganuma Hiroyuki
Research Institute Kagome Co. Ltd.
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米谷 民雄
Division Of Foods National Institute Of Health Sciences
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Inakuma Takahiro
Research Institute Kagome Co. Ltd
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Akiyama Hiroshi
Division Of Novel Foods And Immunochemistry National Institute Of Health Science
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Akiyama Hiroshi
National Food Research Institute National Agriculture And Food Research Organization
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Sato Yuji
National Defense Academy
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Sato Yuji
Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Nagaoka Megumi
National Inst. Of Health Sciences Div. Of Foods Kamiyoga 1-18-1 Setagaya Tokyo 158-8501 Jpn
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Inakuma Takahiro
Research Institute, Kagome Company Ltd.
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