Constituents in Watercress : Inhibitors of Histamine Release from RBL-2H3 Cells Induced by Antigen Stimulation

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概要

• 論文の詳細を見る

• Histamine release inhibitors in watercress (Nasturtium officinale) were isolated using a monitoring system with antigen-stimulated RBL-2H3 cells. Of the 15 compounds isolated, flavonols and megastigmanes significantly inhibited histamine release. Two flavonols, 3-O-sophorosides of rhamnetin and rhamnazin, were new compounds. To investigate the inhibitory mechanism, the effects of rhamnetin, rhamnetin 3-O-sophoroside and an isolated megatigmane glucoside on the increase in the intracellular free calcium concentration were examined at a concentration providing 60% inhibition of histamine release. The results suggest that these compounds did not affect the calcium influx at that concentration. The structure-activity relationships of the megastigmanes on histamine release were also investigated.

• 社団法人日本薬学会の論文
• 1999-12-15

著者

• 合田 幸弘

  国立医薬品食品衛生研究所

• AKIYAMA Hiroshi

  National Institute of Health Sciences

• GODA Yukihiro

  National Institute of Health Sciences

• Takeda Yoshio

  Faculty of Pharmacy, Yasuda Womens University

• Kamada H

  Univ. Tsukuba Tsukuba Jpn

• Goda Y

  National Institute Of Health Sciences

• HOSHINO Kaori

  Showa Women's University

• ISHIKAWA Tomoko

  National Institute of Health Sciences

• ABE Yukiko

  National Institute of Health Sciences

• NAKAMURA Takatoshi

  National Institute of Health Sciences

• OTSUKA Hideaki

  Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine

• TANIMURA Akio

  Showa Women's University

• TOYODA Masataka

  National Institute of Health Sciences

• Higashi K

  Gene Research Center University Of Tsukuba

• Tanimura Akio

  Showa Woman's University

• Toyoda M

  Jissen Women's Univ.

• Toyoda Masatake

  Faculty Of Human Life Sciences Jissen Women's University

• Abe Y

  Kyoritsu Coll. Pharmacy Tokyo Jpn

• Goda Yukihiro

  National Inst. Of Health Sciences

• Takeda Yoshio

  Faculty Of General Arts And Sciences The Tokushima University

• Otsuka Hideaki

  Institute Of Pharmaceutical Sciences Hiroshima University Faculty Of Medicine

• Takeda Mitsuharu

  College Of Bioresource Sciences Nihon University

• Hoshino Kaori

  Showa Women's University

• Akiyama Hiroshi

  Division Of Novel Foods And Immunochemistry National Institute Of Health Science

• Akiyama Hiroshi

  National Food Research Institute National Agriculture And Food Research Organization

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