Antiallergic Effect of Apple Polyphenols on the Allergic Model Mouse
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概要
- 論文の詳細を見る
We studied here the antiallergic effect of apple condensed tannins (ACT) administered orally to a type I allergy model mouse transplanted with an IGEL a2 hybridoma secreting anti-2,4,6-trinitrophenyl (TNP) immunoglobulin E (IgE). The oral administration of ACT significantly inhibited the ear swelling responses at 1 h after antigen-stimulation with picryl chloride. The response was dose dependent within 0.1 to 10 mg/mouse. The inhibition of the ear swelling response reached the maximal level (90% inhibition) when ACT was administered 2 h before the antigen challenge. These findings suggest that ACT has an antiallergic effect on type I allergic symptoms.
- 公益社団法人日本薬学会の論文
- 2000-11-01
著者
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TESHIMA Reiko
National Institute of Health Sciences
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Sawada Junichi
Project Team For Pharmacogenetics National Institute Of Health Sciences
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合田 幸弘
国立医薬品食品衛生研究所
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AKIYAMA Hiroshi
National Institute of Health Sciences
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Teshima Reiko
Division of Biochemistry and Immunochemistry, National Institute of Health Sciences
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Teshima R
National Inst. Of Health Sciences
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Teshima Reiko
国立医薬品食品衛生研究所 機能生化学部
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Teshima Reiko
名古屋市立大学 薬学研究科
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GODA Yukihiro
National Institute of Health Sciences
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TOYODA Masatake
National Institute of Health Sciences
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KOBAYASHI Yuriko
Faculty of Pharmaceutical Sciences, Teikyo University
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KOBAYASHI Yohnosuke
Department of Pediatrics, Kansai Medical University
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TANIUCHI SHOICHIRO
Department of Pediatrics, Kansai Medical University
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Teshima Reiko
National Institute Of Health Science
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Goda Y
National Institute Of Health Sciences
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Kanda T
Nikka Whisky Distilling Co. Ltd. Aomori Jpn
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Toyoda M
Jissen Women's Univ.
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Toyoda Masatake
Faculty Of Human Life Sciences Jissen Women's University
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Goda Yukihiro
National Inst. Of Health Sciences
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Taniuchi Shoichiro
Department Of Paediatrics Kansai Medical University
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Kobayashi Yohnosuke
Department Of Paediatrics Kansai Medical University
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Teshima Reiko
National Inst. Of Health Sciences
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Toyoda M
National Institute Of Health Sciences
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Sawada J
Mie Univ. School Of Medicine Mie Jpn
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Yanagida Akio
Department Of Analytical Chemistry School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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SAKUSHIMA Jun-ichiro
National Institute of Health Sciences
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Kobayashi Y
Faculty Of Pharmaceutical Sciences Teikyo University Sagamiko
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KOJIMA Takatsugu
Department of Pediatrics, Kansai Medical University
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SAKUSHIMA Jun-ichi
National Institute of Health Sciences
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KANDA Tomomasa
Institute for Production Research and Development, The Nikka Whisky Distilling Co., LTD.,
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YANAGIDA Akio
Institute for Production Research and Development, The Nikka Whisky Distilling Co., LTD.,
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Takeda Mitsuharu
College Of Bioresource Sciences Nihon University
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Taniuchi S
Department Of Pediatrics Kansai Medical University
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Kawashima Y
Faculty Of Pharmaceutical Sciences Teikyo University Sagamiko
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Toyoda M
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
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Akiyama Hiroshi
Division Of Novel Foods And Immunochemistry National Institute Of Health Science
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Sawada J
National Inst. Of Health Sci. Tokyo Jpn
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Akiyama Hiroshi
National Food Research Institute National Agriculture And Food Research Organization
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