The Effect of Feeding Carrots on Immunoglobulin E Production and Anaphylactic Response in Mice
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概要
- 論文の詳細を見る
Carrot juice was administered orally to BALB/c mice immunized intraperitoneally with dinitrophenylated(DNP)-OVA for about 1 month. The titers of DNP-specific IgE, DNP-specific IgG, and the levels of total IgE in mouse sera were determined. The DNP-specific IgE production by mice fed carrot juice was significantly ingibited. On the other hand, the DNP-specific IgG production and the level of total IgE in mice fed carrot juice were not significantly different from those in control mice. We also examined the effect of feeding carrots on immediate-type htpersensitivity. One hour after antigen stimulation, the ears of mice fed carrots swelled less than those of control mice. Furthermore, the rise in serum histamine in the mice fed carrots under active systemic anaphylaxis was lower than in controls.We then examined the pattern of cytokine production by spleen cells from mice followed by restimulation with DNP-OVA in vitro. The spleen cells from the mice fed carrots produced more interferon-γ than those form the control group. In contrast, the spleen cells from the mice fed carrots produced less interleukin-4 than those form the control group. Furthermore, the interleukin-12 production of the spleen cells from mice fed carrots was aslo higher than that of the control group. These findings suggest that feeding carrots improves the helper T cell(Th)1/Th2 balance, inhibiting specific IgE production and antigen-induced anaphylactic response.
- 社団法人日本薬学会の論文
- 1999-06-15
著者
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TESHIMA Reiko
National Institute of Health Sciences
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Sawada Junichi
Project Team For Pharmacogenetics National Institute Of Health Sciences
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合田 幸弘
国立医薬品食品衛生研究所
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AKIYAMA Hiroshi
National Institute of Health Sciences
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Sawada Jun-ichi
National Institute Of Health Sciences
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Teshima R
National Inst. Of Health Sciences
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Teshima Reiko
国立医薬品食品衛生研究所 機能生化学部
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GODA Yukihiro
National Institute of Health Sciences
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TOYODA Masatake
National Institute of Health Sciences
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Kamada H
Univ. Tsukuba Tsukuba Jpn
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Teshima Reiko
National Institute Of Health Science
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Goda Y
National Institute Of Health Sciences
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Ito Yasuhiro
Food Biotechnology Div. National Food Res. Inst.
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Ishiguro Yukio
Research Institute Kagome Co. Ltd.
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HOSHINO Kaori
Showa Women's University
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TOKUZUMI Maho
Showa Women's University
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MORI Hironobu
Research Institute, Kagome Co., Ltd.,
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INAKUMA Takahiro
Research Institute, Kagome Co., Ltd.,
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Higashi K
Gene Research Center University Of Tsukuba
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Toyoda M
Jissen Women's Univ.
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Toyoda Masatake
Faculty Of Human Life Sciences Jissen Women's University
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Goda Yukihiro
National Inst. Of Health Sciences
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Moriya H
Department Of Pathology Gifu University School Of Medicine
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Teshima Reiko
National Inst. Of Health Sciences
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Sawada J
Mie Univ. School Of Medicine Mie Jpn
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Tokuzumi Maho
Showa Women's University
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Inakuma T
Kagome Co. Ltd.
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Inakuma Takahiro
Res. Inst. Kagome Co. Ltd.
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Takeda Mitsuharu
College Of Bioresource Sciences Nihon University
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Inakuma Takahiro
Research Institute Kagome Co. Ltd
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Mori Hironobu
Research Institute Kagome Co. Ltd.
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Hoshino Kaori
Showa Women's University
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Akiyama Hiroshi
Division Of Novel Foods And Immunochemistry National Institute Of Health Science
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Sawada J
National Inst. Of Health Sci. Tokyo Jpn
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Akiyama Hiroshi
National Food Research Institute National Agriculture And Food Research Organization
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Inakuma Takahiro
Research Institute, Kagome Company Ltd.
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ISHIGURO Yukio
Research Institute, Kagome Co., Ltd.,
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