In Vitro Effects of Synthetic Dyes on the Syntheses of Prostaglandin E_2 (PGE_2) and 5-Hydroxyeicosatetraenoic Acid (5-HETE)
スポンサーリンク
概要
- 論文の詳細を見る
The effects of thirty-one synthetic dyes (tar dyes in Japan), which are permitted in cosmetics, on three different enzymes were evaluated as an initial step in developing in vitro safety screens. The activities of the prostaglandin (PG)-synthetase from rabbit renal medulla and the lipoxygenases from potato tubers and guinea pig peritoneal polymorphonuclear leukocytes (PMN) were determined based on the biosyntheses of PGE_2 and 5-hydroxyeicosatetraenoic acid (5-HETE), respectively. Xanthene dyes with halogen substituents exhibited marked inhibition on the PG-synthetase. Among the dyes which are permitted for any pharmaceutics and cosmetics, only the xanthene dyes exhibitec inhibitory effects on the PG-synthetase at 2.5 mM. The xanthene dyes also showed inhibition and stimulation of potato lipoxygenase and PMN lipoxygenase, respectively.
- 社団法人日本薬学会の論文
著者
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Maitani Tamio
National Institute of Health Sciences
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GODA Yukihiro
National Institute of Health Sciences
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Yamazaki Takeshi
Graduate School Of Science And Technology Niigata University
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Yamazaki Takeshi
National Institute Of Health Sciences
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Goda Yukihiro
National Institute Of Health Sciences (formerly National Institute Of Hygienic Sciences)
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Maitani Tamio
National Institute Of Health Sciences (nihs)
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YOSHIHIRA Kunitoshi
National Institute of Hygienic Sciences
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KAWASAKI Yoko
National Institute of Health Sciences
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Goda Y
National Inst. Health Sci. Tokyo Jpn
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Goda Yukihiro
National Inst. Of Health Sciences
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Maitani Tamio
National Institute For Environmental Studies
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Kawasaki Y
National Institute Of Health Sciences
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Yamazaki T
Division Of Food Additives National Institute Of Health Sciences
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Yoshihira K
National Institute Of Health Sciences (formerly National Institute Of Hygienic Sciences)
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Yoshihira Kunitoshi
National Institute Of Health Sciences (formerly National Institute Of Hygienic Sciences)
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Yamazaki Takeshi
National Agricultural Research Center For Hokkaido Region National Agriculture And Food Research Org
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Yamada Takashi
National Institute Of Health Sciences (formerly National Institute Of Hygienic Sciences)
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YOSHIHIRA KUNITOSHI
National Institute of health Sciences
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