Identification of a Cannabinoid Analog as a New Type of Designer Drug in a Herbal Product(Communications to the Editor)

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概要

• 論文の詳細を見る

• A new type of designer drug, a cannabinoid analog (1), was found in a herbal product distributed on the illegal drug market in Japan in expectation of its narcotic effect. The structure of 1 was identified by LC-MS, GC-MS, high-resolution MS, and NMR analyses. Compound 1 showed a molecular weight of 332, and accurate mass measurement exhibited its elemental composition to be C_<22>H_<36>O_2. Together, the mass and NMR spectrometric data revealed that 1 was (1RS,3SR)-3-[4-(1,1-dimethyloctyl)-2-hydroxyphenyl]cyclohexan-1-ol, which was first synthesized in 1979 by a group at Pfizer Inc. and reported as a potent cannabinoid analog possessing cannabinoid receptor binding activity and analgesic activity in the 1990s. This is the first report to identify a cannabinoid analog in an illegal drug.

• 公益社団法人日本薬学会の論文
• 2009-04-01

著者

• GODA Yukihiro

  National Institute of Health Sciences

• HAISHIMA Yuji

  National Institute of Health Sciences

• KAWAHARA Nobuo

  National Institute of Health Sciences

• Uchiyama N

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Uchiyama Nahoko

  National Institute Of Health Sciences

• Goda Yukihiro

  National Inst. Of Health Sciences

• Guo Yahong

  Graduate School Of Pharmaceutical Sciences Nagoya City University

• Kawahara Nobuo

  Division Of Pharmacognosy Phytochemistry And Narcotics National Institute Of Health Sciences

• Kikura-hanajiri Ruri

  National Institute Of Health Sciences

• Kawahara Nobuo

  National Inst. Health Sci. Tokyo Jpn

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