Neurite Outgrowth-Promoting Active Constituents of the Japanese Cypress (Chamaecyparis obtusa)
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概要
- 論文の詳細を見る
In the screening of biologically active constituents from woody plants, the methanol extract of leaves of Chamaecyparis obtusa showed potent neurite outgrowth-promoting activity in neuronal PC12 cells. The ethyl acetate-soluble fraction of the methanol extract showed potent activity and was separated by means of various chromatographic methods to give the two new compounds 1 and 2, as well as 11 known lignan and sesquiterpene derivatives. The structures of the new compounds were determined to be 9-O-acetyldihydrosesamin (1) and 9-O-(11-hydroxyeudesman-4-yl)dihydrosesamin (2), respectively, in NMR studies including 2D-NMR experiments. Of the 13 compounds, the known compound hinokinin (5) and the new compound 2 showed potent neurite outgrowth-promoting activity in PC 12 cells.
- 社団法人日本薬学会の論文
- 2008-01-01
著者
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KAWAHARA Nobuo
National Institute of Health Sciences
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NAKANE Takahisa
Showa Pharmaceutical University
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KUROYANAGI Masanori
Faculty of Life and Enviromental Sciences, Prefectural University of Hiroshima
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Gao H
School Of Traditional Chinese Medicines Shenyang Pharaceutical University
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Gao Hui
School Of Traditional Chinese Medicines Shenyang Pharmaceutical University
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Kuroyanagi M
Fac. Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri Univ.
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Muto Norio
Faculty Of Life And Environmental Sciences Prefectural University Of Hiroshima
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SANO Toshikazu
Hiroshima Prefectural Forestry Research Center
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IKEDA Ryuya
Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima
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OTAKI Keisuke
Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima
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Ikeda Ryuya
Faculty Of Life And Environmental Sciences Prefectural University Of Hiroshima
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Otaki Keisuke
Faculty Of Life And Environmental Sciences Prefectural University Of Hiroshima
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Nakane Takahisa
Biological Sci. Res. Lab. Lion Corp.
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Nakane Takahisa
Showa Pharmaceutical Univ.
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Muto Norio
Faculty Of Life And Environmental Science Prefectural University Of Hiroshima
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Kawahara N
National Institute Of Health Sciences
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Kuroyanagi Masanori
Fac. Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri Univ.
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川原 信夫
National Institute Of Health Sciences
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Kuroyanagi Masanori
Faculty Of Food Culture Department Of Nutrition Kurashiki Sakuyo University
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Kimura Mariko
Fac. Of Food Culture Dep. Of Nutrition Kurashiki Sakuyo Univ.
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Kawahara Nobuo
Tsukuba Div. Res. Center For Medicinal Plant Resources National Inst. Of Biomedical Innovation
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Kawahara Nobuo
National Inst. Health Sci. Tokyo Jpn
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Nakane Takahisa
Showa Parmaceutical University
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GAO Hui
School of Information and Communication Engineering, Beijing University of Posts and Telecommunications
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