Polyprenylated Benzoylphloroglucinol-Type Derivatives Including Novel Cage Compounds from Hypericum erectum
スポンサーリンク
概要
- 論文の詳細を見る
Hyperici erecti herba (Hypericum erectum THUNB.) showed a suppressive effect on generation of isovaleric acid by Corynebacterium xerosis. An ethyl acetate (AcOEt) soluble fraction of methanol extract of H. erectum showed the activity. The AcOEt fraction was separated by various successive choromatographical methods to give seven new compounds 1—7 along with some known compounds. The structures of the new compounds were elucidated to be polyprenylated benzoylphloroglucinol derivatives by means of HR-MS and NMR spectra including 2D-NMR. Some of these compounds had novel cage structures having benzoyltricyclo[3,3,1,13,7]decane and benzoyltricyclo[4,3,1,13,8]undecane skeletons arising from a polyprenylated phloroglucinol precursor by a transannular cyclization reaction. The isolated compounds were tested for suppressive activity, but they showed only weak activity.
- 公益社団法人 日本薬学会の論文
著者
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SHIROTA Osamu
Faculty of Pharmaceutical Sciences, Kagawa Campus, Tokushima Bunri University
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SEKITA Setsuko
Faculty of Pharmaceutical Sciences, Kagawa Campus, Tokushima Bunri University
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KUROYANAGI Masanori
Faculty of Life and Enviromental Sciences, Prefectural University of Hiroshima
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Shirota Osamu
Faculty Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri University
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Sekita Setsuko
大阪府立公衆衛生研究所
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Sekita S
Division Of Pharmacognosy Phytochemistry And Narcotics National Institute Of Health Sciences
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Sekita Setsuko
National Institute Of Health Sciences
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Sekita Setsuko
Faculty Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri University
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Nakane Takahisa
Biological Sci. Res. Lab. Lion Corp.
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Sekita Setsuko
湧永製薬ヘルスケア研究所
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Ishida Yohei
Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima
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Someya Keita
Showa Pharmaceutical University
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Tokita Fumihiko
Showa Pharmaceutical University
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Kuroyanagi Masanori
Faculty Of Food Culture Department Of Nutrition Kurashiki Sakuyo University
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Ohta Sanae
Laboratory Of Pharmacognosy And Natural Product Chemistry Faculty Of Pharmaceutical Sciences At Kaga
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Sekita S
Laboratory Of Pharmacognosy And Natural Product Chemistry Faculty Of Pharmaceutical Sciences At Kaga
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Sekita Setsuko
Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University
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Sekita Setsuko
Faculty of Pharmaceutical Sciemces at Kagawa Campus, Tokushima Bunri Universiyty
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Shirota Osamu
Faculty of Pharmaceutical Sciemces at Kagawa Campus, Tokushima Bunri Universiyty
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Nakane Takahisa
Biological Science Research Laboratory, Lion Corporation
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Kuroyanagi Masanori
Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University
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